PMID: 8609263Mar 1, 1996Paper

A comparison of the efficacy and safety of adapalene gel 0.1% and tretinoin gel 0.025% in the treatment of acne vulgaris: a multicenter trial

Journal of the American Academy of Dermatology
A ShalitaJ Czernielewski

Abstract

Adapalene is a new synthetic retinoid analogue developed for the topical treatment of acne vulgaris. The study was designed to compare the efficacy and safety and adapalene gel 0.1% with tretinoin gel 0.025% in the treatment of grade II to II facial acne vulgaris. Three hundred twenty-three patients were enrolled in this investigator-masked, randomized, parallel group, multicenter trial. Patients applied the test materials to the entire facial area daily, for a period of 12 weeks. Efficacy and cutaneous tolerance were assessed at baseline and weeks 2,4,8, and 12. Efficacy was determined by investigator counts of noninflammatory open and closed comedones, and inflammatory papules and pustules, as well as global improvement. Cutaneous tolerance was evaluated by erythema, scaling, and dryness, along with burning and pruritus. Staring at weeks 2 and 4, adapalene gel produced numerically greater lesion reductions than did tretinoin gel for all lesion types. At week 12, the mean percent reduction in the different lesion counts was as follow: 49% versus 37% for total lesions (p<0.01); 46% versus 33% for noninflammatory lesions (p=0.02); 48% versus 38% for inflammatory lesions (p=0.06) in adapalene and tretinoin gel treatment groups, r...Continue Reading

References

Apr 1, 1991·The British Journal of Dermatology·M VerschooreH Schaefer
Sep 1, 1988·Journal of the American Academy of Dermatology·D J Elbaum
Jul 1, 1984·The British Journal of Dermatology·B M Burke, W J Cunliffe

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Citations

Jul 1, 1997·Journal of Clinical Pharmacology·T S HindsE M Knight
Jan 22, 2000·Advances in Dermatology·G M White
Aug 16, 2000·Pediatric Clinics of North America·D P Krowchuk
Jul 4, 1998·Lancet·S K Brown, A R Shalita
Aug 14, 1998·Journal of the American Academy of Dermatology·J S Weiss, J S Shavin
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·J CzernielewskiJ C Hensby
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·L E Millikan
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·J E Wolf
Feb 15, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·A Shalita
Feb 17, 1999·The British Journal of Dermatology·S A GalvinM R Tuley
Jun 10, 2000·The British Journal of Dermatology·W J CunliffeG I Stables
Nov 30, 2000·International Journal of Dermatology·L E Millikan
Apr 9, 2005·The New England Journal of Medicine·William D James
Oct 18, 2006·Journal of Lower Genital Tract Disease·P A DiSilvestroR S Mannel
Jan 19, 1999·Journal of the European Academy of Dermatology and Venereology : JEADV·H Gollnick, M Schramm
Jun 3, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Douglas E Kligman, Zoe Diana Draelos
Jan 22, 1998·Pediatric Dermatology·J S Weiss
Apr 17, 2004·Skin Pharmacology and Physiology·A RoederH C Korting
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·B DrénoC Carré
Feb 23, 2005·Dermatology : International Journal for Clinical and Investigative Dermatology·A D Katsambas
Mar 23, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Brigitte DrenoAmir Khammari
Jun 22, 2011·Clinical, Cosmetic and Investigational Dermatology·Kristen M Whitney, Chérie M Ditre
Jun 20, 2003·American Journal of Clinical Dermatology·Arash Akhavan, Susan Bershad
Jan 29, 2005·American Journal of Clinical Dermatology·Martine Chivot
May 17, 2011·Indian Journal of Dermatology·Sanjay K Rathi
Feb 22, 2016·Journal of the American Academy of Dermatology·Andrea L ZaengleinKevin M Boyer
May 10, 2011·Journal of the American Academy of Dermatology·Stanley ShapiroStephan Lanes
Aug 15, 2000·Pediatric Annals·R Sidbury, A S Paller
Oct 12, 2001·Seminars in Cutaneous Medicine and Surgery·S Bershad
Mar 31, 2012·Journal of the European Academy of Dermatology and Venereology : JEADV·A NastUNKNOWN European Dermatology Forum
Jan 11, 2013·Journal of the European Academy of Dermatology and Venereology : JEADV·B DrénoJ C Harper
Dec 16, 2011·The Journal of Dermatology·Kumiko TaguchiChikako Nishigori
Nov 24, 2004·Clinics in Dermatology·Dimitris RigopoulosAndreas D Katsambas
Jan 31, 2006·Journal of the American Academy of Dermatology·Diane ThiboutotUNKNOWN Adapalene Study Group
Aug 14, 1998·Journal of the American Academy of Dermatology·A M Kligman
Jun 1, 1997·Journal of the American Academy of Dermatology·M VerschooreA Clucas
Jun 1, 1997·Journal of the American Academy of Dermatology·A ClucasJ Czernielewski

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