A comparison of the efficacy of carbamazepine and the novel anti-epileptic drug levetiracetam in the tetanus toxin model of focal complex partial epilepsy

British Journal of Pharmacology
H C DohenyP N Patsalos

Abstract

1. The tetanus toxin seizure model, which is associated with spontaneous and intermittent generalized and non-generalized seizures, is considered to reflect human complex partial epilepsy. The purpose of the present study was to investigate and compare the anticonvulsant effects of carbamazepine with that of levetiracetam, a new anti-epileptic drug in this model. 2. One microl of tetanus toxin solution (containing 12 mLD(50) microl(-1) of tetanus toxin) was placed stereotactically into the rat left hippocampus resulting in generalized and non-generalized seizures. 3. Carbamazepine (4 mg kg(-1) h(-1)) and levetiracetam (8 and 16 mg kg(-1) h(-1)) were administered during a 7 day period via an osmotic minipump which was placed in the peritoneal cavity. Carbamazepine (4 mg kg(-1) h(-1)) exhibited no significant anticonvulsant effect, compared to control, when the entire 7 day study period was evaluated but the reduction in generalized seizures was greater (35.5%) than that for non-generalized seizures (12.6%). However, during the first 2 days of carbamazepine administration a significant reduction in both generalized seizure frequency (90%) and duration (25%) was observed. Non-generalized seizures were unaffected. This time-depende...Continue Reading

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Citations

Sep 17, 2015·Journal of Neuroscience Methods·Katie LidsterMark J Prescott
May 12, 2015·Journal of Neuroscience Methods·John JefferysPeter Bedner
Oct 23, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Amy J HallidayMark J Cook
Jun 19, 2007·Epilepsia·Lawrence J HirschCarl W Bazil
Jun 14, 2008·Journal of Neuroscience Methods·Giulia CuriaMassimo Avoli
Jun 28, 2008·Epilepsy & Behavior : E&B·C HelmstaedterC E Elger
Mar 23, 2018·Reviews in the Neurosciences·Nikita NirwanDivya Vohora
Feb 12, 2020·Clinical Chemistry and Laboratory Medicine : CCLM·Thierry P I J M CanisiusH J Marian Majoie

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