A comparison of the efficacy, safety, and patient satisfaction of ondansetron versus droperidol as antiemetics for elective outpatient surgical procedures. S3A-409 and S3A-410 Study Groups

Anesthesia and Analgesia
J T FortneyM R Creed

Abstract

Two identical, randomized, double-blind, placebo-controlled studies enrolled 2061 adult surgical outpatients at high risk of postoperative nausea and vomiting (PONV) to compare i.v. ondansetron 4 mg with droperidol 0.625 mg and droperidol 1.25 mg for the prevention of PONV. The antiemetic drugs or placebo were administered i.v. 20 min before the induction of anesthesia with a barbiturate compound, followed by maintenance with N2O/isoflurane/enflurane. Nausea, emetic episodes, adverse events, and patient satisfaction were analyzed for the 0 to 2 h and 0 to 24 h postoperative periods. In the 0 to 2 h postoperative period, there was a complete response (no emesis or rescue antiemetic) in 46% of subjects given placebo (P < 0.05 versus antiemetic groups), in 62% given ondansetron, in 63% given droperidol 0.625 mg, and in 69% given droperidol 1.25 mg (P < 0.05 versus ondansetron). In the 0 to 24-h postoperative period, there were no significant differences in complete response between the ondansetron and droperidol 0.625 or 1.25 mg groups; all groups remained superior to placebo. The proportion of patients without nausea during the 0 to 24 h postoperative period was greater in the antiemetic groups compared with the placebo group; ho...Continue Reading

References

Dec 1, 1989·JAMA : the Journal of the American Medical Association·B S GoldJ M Neuhaus
Jan 1, 1988·General Pharmacology·L StatileH Turndorf
Mar 1, 1984·Canadian Anaesthetists' Society Journal·M G Palazzo, L Strunin
Jan 1, 1995·Paediatric Anaesthesia·R J Mawer, P M Spargo
Sep 1, 1994·Journal of Clinical Anesthesia·M F Watcha, I Smith

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Citations

Apr 6, 2004·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Ashraf S Habib, Tong J Gan
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·O WuG Koutsoukos
Jun 30, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·I HenziM R Tramèr
Oct 14, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·P S LoewenP J Zed
Nov 17, 2007·Journal of Anesthesia·Hiroaki MitsunariKumiko Tanaka
Jan 1, 2010·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Rajeev Sharma, Asish Panda
Mar 14, 2001·Anesthesiology Clinics of North America·I Smith
Feb 5, 2003·Journal of Clinical Anesthesia·Mark Dershwitz
Jul 9, 1999·Journal of Clinical Anesthesia·F J OverdykJ Marcell
Aug 18, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J L ParlowN Avery
Nov 25, 2003·British Journal of Anaesthesia·J L JorisM L Lamy
May 14, 2009·Therapeutics and Clinical Risk Management·Neil A Muchatuta, Michael J Paech
Nov 11, 2009·Hand : Official Journal of the American Association for Hand Surgery·Rebecca NelsonDon Lalonde
Jul 29, 2008·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Christy NunleyCherry Guinn
Dec 16, 2006·Journal of Perianesthesia Nursing : Official Journal of the American Society of PeriAnesthesia Nurses·Julie Golembiewski, Sheri Tokumaru
Oct 15, 2009·Anaesthesia·J R Sneyd
Jul 24, 2004·Seminars in Pediatric Surgery·John David EmhardtPornarun Sirichotvithyakorn
Mar 7, 2006·Journal of Clinical Anesthesia·Frederic J GergesSamar I Jabbour-Khoury
Jun 19, 2003·Anesthesiology Clinics of North America·David Cameron, Tong Joo Gan
Jan 15, 2013·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Danielle CruthirdsPatrick J Louis
Dec 3, 2014·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Carolyn Dicus BrookesJay Anderson
Dec 21, 2013·Anesthesia and Analgesia·Tong J GanUNKNOWN Society for Ambulatory Anesthesia
Feb 8, 2014·European Journal of Anaesthesiology·John P HenaoBrian A Williams
Jul 6, 2013·Cephalalgia : an International Journal of Headache·Sanjay PrakashAditi Trivedi
Oct 24, 2003·International Anesthesiology Clinics·Phillip E Scuderi
Oct 24, 2003·International Anesthesiology Clinics·Phillip E Scuderi, Lydia A Conlay
Apr 24, 2004·Anesthesia and Analgesia·Yongfeng ZhangPaul F White
Oct 23, 2003·Anesthesia and Analgesia·Ashraf S Habib, Tong J Gan
Jan 27, 2004·Anesthesia and Analgesia·Ashraf S Habib, Tong J Gan
Jun 24, 2003·Anesthesia and Analgesia·Tong J GanUNKNOWN Department of Anesthesiology, Duke University Medical Center

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