PMID: 8938364Feb 1, 1996Paper

A comparison of the hemodynamic and ventilatory effects of abdominal insufflation with helium and carbon dioxide in young swine

Journal of Pediatric Surgery
T LiemW Chen

Abstract

Abdominal CO2 insufflation has been shown to cause hypercarbia, acidemia, and decreased oxygenation in a pediatric animal model. Such metabolic derangements have prompted a search for alternative insufflation gases. This study compares the hemodynamic and ventilatory changes that occur during pneumoperitoneum with CO2 and helium. Four juvenile swine were intubated and given general anesthesia. Minute ventilation was adjusted to obtain a baseline Pco2 of between 32 and 36 mm Hg, and was kept constant for the duration of the experiment. The subjects initially were insufflated with CO2 or helium at a pressure of 10 mm Hg. Peak ventilatory pressure, end-tidal CO2 (ETCO2) arterial pH, Pco2, Po2, and right atrial and inferior vena caval pressures were measured before and during a 1-hour insufflation period. After desufflation, Pco2 and pH were restabilized. The same parameters were then measured during reinsufflation with the alternate gas. CO2 insufflation caused significant decreases in pH, from 7.51 +/- 0.03 to 7.32 +/- 0.06, and Po2 increased from 261 +/- 49 to 189 +/- 33 mm Hg. Pco2 increased from 35.0 +/- 1.4 to 57.9 +/- 6.3 mm Hg. ETCO2 also increased, from 29.0 +/- 2.2 to 47.2 +/- 5.0 mm Hg. Helium insufflation caused pH to d...Continue Reading

References

Feb 1, 1992·Journal of Pediatric Surgery·K F Heiss, B Shandling
Aug 1, 1991·Archives of Surgery·C M WittgenD L Kaminski
Oct 1, 1991·Journal of Pediatric Surgery·G W HolcombK W Sharp
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Mar 1, 1993·Journal of Pediatric Surgery·T E LobeK Lunsford

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Citations

Mar 24, 2004·Fertility and Sterility·Carlos Roger MolinasPhilippe Robert Koninckx
Jun 2, 1998·Journal of Endourology·D C O'SullivanL R Kavoussi
Jan 8, 2010·Surgical Endoscopy·Jan Paul J MulierSebastiaan Van Cauwenberge
Dec 6, 2011·Respiratory Physiology & Neurobiology·Hanna RunckJosef Guttmann
Jul 9, 2002·The Journal of the American Association of Gynecologic Laparoscopists·Ospan A MynbaevPhilippe R Koninckx
Jun 5, 2003·Pediatrics·Jeffrey L Zitsman

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