A comparison of the insulin-sensitive transport of chromium in healthy and model diabetic rats

Journal of Inorganic Biochemistry
Buffie J ClodfelderJohn B Vincent

Abstract

In response to insulin, chromium(III) is moved from the blood to the tissues where it is ultimately lost in the urine, apparently as the oligopeptide chromodulin; this transfer of chromium is mediated by the protein transferrin. To examine the effects of type 1 and type 2 diabetes on the transport of chromium, the fate of chromium from intravenously introduced (51)Cr(2)-labelled transferrin was monitored after 2 h in healthy and diabetic model rats; the effects of insulin on the transport of chromium in these groups were also examined. Diabetic rats had greater urinary chromium loss, greater movement of chromium from the blood to the tissues, most notably to the skeletal muscle, and an alteration of the distribution of chromium in the blood plasma.

Citations

Jan 9, 2013·Biological Trace Element Research·Sharifa T LoveJohn B Vincent
Mar 7, 2012·Biological Trace Element Research·Nicholas R RhodesJohn B Vincent
Apr 28, 2005·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Buffie J Clodfelder, John B Vincent
Jun 17, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·C Derrick QuarlesJulia L Brumaghim
Jul 17, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Jan 22, 2008·Journal of Mass Spectrometry : JMS·Dan PuCarolyn J Cassady
Jul 4, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M Jason HatfieldJohn B Vincent
Aug 30, 2005·Metabolism: Clinical and Experimental·Mahmood S MozaffariStephen W Schaffer
Apr 18, 2015·British Journal of Pharmacology·Geng-Ruei ChangFrank Chiahung Mao
Jul 26, 2011·Biochimica Et Biophysica Acta·John B Vincent, Sharifa Love
Jan 18, 2015·Biological Trace Element Research·John B Vincent
Sep 24, 2011·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ewelina Król, Zbigniew Krejpcio
Apr 23, 2013·Chemico-biological Interactions·C R KirmanS M Hays
Apr 8, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·John B Vincent
Apr 22, 2011·Metallomics : Integrated Biometal Science·C Derrick QuarlesR Kenneth Marcus
Jun 22, 2019·The British Journal of Nutrition·Suzie Ferrie
Sep 15, 2012·Chemistry & Biodiversity·John B Vincent, Sharifa T Love
Mar 8, 2020·Biological Trace Element Research·Mikhail Yu KarganovAnatoly V Skalny

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