PMID: 9523811Apr 2, 1998Paper

A comparison of the intubation conditions between mivacurium and rocuronium during balanced anesthesia

Anesthesiology
R M PinoA E Schwartz

Abstract

Comparisons of the intubation conditions with mivacurium and rocuronium from previous reports are confounded by the use of varied induction regimens. The authors compared intubation conditions of mivacurium, rocuronium, and a placebo at 90 s and their recovery profiles during anesthesia with nitrous oxide, oxygen, and propofol. After induction with midazolam, fentanyl, and propofol in a randomized blinded study, 100 patients received one of the following treatments: 0.25 mg/kg mivacurium in divided doses (0.15 mg/kg followed by 0.1 mg/kg 30 s later); 0.45, 0.6, 0.9, or 1.2 mg/kg rocuronium; or placebo. Evoked thumb adduction was measured throughout. Intubation was attempted 90 s after the initial dose of mivacurium and other treatment doses by a "blinded" physician. Intubating conditions were graded as excellent, good, poor, or not possible. Spontaneous recovery was studied until a 25% initial twitch height was reached. Mean arterial blood pressure and heart rate changes between groups were determined before induction through 6 min after administration of the study drugs. There were no important changes or intergroup differences in mean arterial blood pressure and heart rate. Intubation conditions were good or excellent for bot...Continue Reading

References

Nov 1, 1992·British Journal of Anaesthesia·M MayerK Peter
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Apr 1, 1989·Anesthesia and Analgesia·D R CookR M Welch
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Citations

Feb 1, 2003·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Thomas LieutaudBertrand Debaene
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·C Motamed, F Donati
Oct 3, 2006·Current Opinion in Anaesthesiology·A Diez R-Labajo
Oct 25, 2003·Anesthesiology·Mohamed NaguibSaleh W Alharby
Apr 17, 2004·Anesthesiology·James E Caldwell
Mar 26, 2005·Anesthesiology·Cynthia A LienPaul M Heerdt
Feb 6, 2016·Acta Anaesthesiologica Scandinavica·Aaron F Kopman, Mohamed Naguib
Jun 16, 2005·Acta Anaesthesiologica Scandinavica·Y LeykinA Gullo
Apr 6, 2013·Journal of Evidence-based Medicine·Rao SunNong Cao
Dec 22, 1999·The American Journal of Emergency Medicine·S L Orebaugh
Sep 17, 2016·Anesthesia and Analgesia·Aaron F Kopman, Mohamed Naguib
Sep 24, 2004·Anesthesia and Analgesia·Yigal LeykinAntonino Gullo
Jan 12, 2020·Anaesthesia Critical Care & Pain Medicine·Benoît PlaudBertrand Debaene

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