A comparison of the metabolism of radioactive 17-isoaldosterone and aldosterone administered intravenously and orally to normal human subjects

The Journal of Clinical Investigation
C FloodS Willoughby

Abstract

After intravenous and oral administration of radioactive aldosterone to normal subjects, 7.3 +/- 0.4 (SE) and 5.4 +/- 0.5 (SE)%, respectively, of the dose was recovered from a 48-hour collection of urine as aldosterone released by mild acid hydrolysis (from aldosterone 18-glucuronide), and 35 +/- 5 (SE) and 39 +/- 4 (SE)%, respectively, was recovered as tetrahydroaldosterone after incubation with beta-glucuronidase.After intravenous and oral administration of 17-isoaldosterone-4-(14)C to a similar group of subjects, 35 +/- 3 (SE) and 53 +/- 4 (SE)%, respectively, of the dose was recovered as 17-isoaldosterone released by acid and less than 5% as total metabolites after incubation with beta-glucuronidase. No detectable radioactivity (< 0.5%) could be recovered as tetrahydroaldosterone or as a compound with the expected chromatographic properties of tetrahydro-17-isoaldosterone. The total radioactivity in the neutral extracts was also relatively small (< 2%) after administration of either labeled aldosterone or 17-isoaldosterone. The radioactivity as aldosterone in the neutral extract was much lower after oral [0.017 +/- 0.003 (SE)%] than after intravenous [0.21 +/- 0.04 (SE)%] administration of labeled aldosterone. The radioacti...Continue Reading

References

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Mar 1, 1959·Acta Endocrinologica·K M JONESF C GREENWOOD
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Citations

May 1, 1988·Pflügers Archiv : European journal of physiology·D l'AllemandK Hierholzer
Sep 1, 1977·Clinica Chimica Acta; International Journal of Clinical Chemistry·A J de Man, T J Benraad
May 12, 2004·Molecular and Cellular Endocrinology·Sylvia A S TaitJohn P Coghlan
Jun 1, 1967·The Journal of Clinical Investigation·C FloodS Willoughby
Nov 1, 1969·The Journal of Clinical Investigation·J F Tait, B Little

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