A Comparison of the Nephrotoxicity of Low Doses of Cadmium and Lead

Toxics
Soisungwan SatarugDavid A Vesey

Abstract

Environmental exposure to moderate-to-high levels of cadmium (Cd) and lead (Pb) is associated with nephrotoxicity. In comparison, the health impacts of chronic low-level exposure to Cd and Pb remain controversial. The aim of this study was to therefore evaluate kidney dysfunction associated with chronic low-level exposure to Cd and Pb in a population of residents in Bangkok, Thailand. The mean age and the estimated glomerular filtration rate (eGFR) for 392 participants (195 men and 197 women) were 34.9 years and 104 mL/min/1.73 m2, respectively, while the geometric mean concentrations of urinary Cd and Pb were 0.25 μg/L (0.45 μg/g of creatinine) and 0.89 μg/L (1.52 μg/g of creatinine), respectively. In a multivariable regression analysis, the eGFR varied inversely with blood urea nitrogen in both men (β = -0.125, p = 0.044) and women (β = -0.170, p = 0.008), while inverse associations of the eGFR with urinary Cd (β = -0.132, p = 0.043) and urinary Pb (β = -0.130, p = 0.044) were seen only in women. An increased urinary level of Cd to the median level of 0.38 μg/L (0.44 μg/g of creatinine) was associated with a decrease in the eGFR by 4.94 mL/min/1.73 m2 (p = 0.011). The prevalence odds of a reduced eGFR rose 2.5-, 2.9- and 2.3-...Continue Reading

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Citations

May 31, 2020·Biological Trace Element Research·Moragoda Kankanamalage Jayani Chathurnima RajathejaGuttila Yugantha Jayasinghe
Sep 29, 2020·Frontiers in Cell and Developmental Biology·Frank ThévenodMichael D Garrick
Oct 18, 2020·Toxics·Soisungwan SatarugKenneth R Phelps
Jul 13, 2021·Frontiers in Aging Neuroscience·Tahir AliMyeong Ok Kim

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