PMID: 8585122Oct 1, 1995Paper

A comparison of the OPUS and TDx analysers for antiepileptic drug monitoring

Therapeutic Drug Monitoring
M T O'ConnellP N Patsalos

Abstract

Therapeutic drug monitoring of a variety of antiepileptic drugs is used routinely as a guide to individualising the drug treatment of patients with epilepsy. Thin dry film multilayer immunoassays (OPUS) for carbamazepine, phenytoin, phenobarbitone, and valproic acid were evaluated and compared with fluorescence polarisation immunoassay (TDx), using commercially available control material and patient sera. For the OPUS, the within-batch coefficient of variation (CV) for the different drugs in the control material varied between 3.9% (phenobarbitone) and 8.1% (valproic acid). The between-batch CVs varied between 5.3% (valproic acid) and 18.3% (carbamazepine). The comparative between-batch CVs for the TDx varied between 2.0% (phenytoin) and 7.0% (valproic acid). Analysis of 209 patient samples containing carbamazepine, phenytoin, phenobarbitone, or valproic acid demonstrated significant correlation between the two analytical methods, with correlation coefficients of 0.9336, 0.9560, 0.9448, and 0.9618, with slopes of the regression lines of 0.9042, 0.8663, 1.1368, and 1.1244, respectively. It is concluded that both the TDx and OPUS instruments exhibit comparable performance for the analysis of carbamazepine, phenobarbitone, phenyto...Continue Reading

Citations

Mar 1, 2000·Biomedical Chromatography : BMC·Y Martín-BioscaM J Medina-Hernández
Aug 29, 2000·Biomedical Chromatography : BMC·C Quiñones-TorreloM J Medina-Hernández
Jan 29, 2003·International Journal of Pharmaceutics·Venkatramana M RaoYihong Qiu
May 22, 2001·Therapeutic Drug Monitoring·Y IidaA Asada
Jun 24, 2020·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Marco TuccoriCorrado Blandizzi
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·J ZhangH B Halsall

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