PMID: 9422176Mar 1, 1995Paper

A comparison of the prognostic value of neuron-specific enolase serum levels and somatosensory evoked potentials in 13 reanimated patients

European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine
T StelzlK A Flugel

Abstract

Thirteen patients resuscitated after circulatory arrest due to cardiopulmonary aetiologies were studied with regard to survival and outcome. Exclusion criteria were known central nervous system disorders or death secondary to cerebrovascular accident. The serum level of neuron-specific enolase (NSE), presumably a reliable marker of neuronal death, was measured by enzyme immunoassay in peripheral blood samples over the course of 4 days at 12 h intervals. On the first and third day post-resuscitation, median nerve somatosensory evoked potentials (SSEPs) were recorded and evaluated for the absence of the cortical potential--presently the standard approach for assessing prognosis in terms of post-resuscitation hypoxaemic brain damage. Absent cortical potentials were found in six patients with NSE levels above 140 micrograms l-1. Five of these patients died; one patient survived with loss of cortical functioning. Five patients had normal SSEP findings, and their NSE maximum levels were below 25 micrograms l-1. All five patients survived without neurological deficits. One patient with a peak NSE level of 36 micrograms l-1 on the second day developed a prolonged delirium (according to DSM III-R criteria) and one patient with a peak le...Continue Reading

Citations

Jul 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·P PereL Lindgren
Jul 25, 2009·Critical Care : the Official Journal of the Critical Care Forum·Koichiro ShinozakiHiroyuki Hirasawa
Mar 27, 2012·International Journal of Speech-language Pathology·Anne LowellSandra Dunn
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Feb 21, 2003·Intensive Care Medicine·Iwan A MeynaarDurk F Zandstra
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Feb 6, 2017·Neurophysiologie clinique = Clinical neurophysiology·Jan H Baars, Jan-Philipp von Klitzing
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May 8, 2018·Journal of Molecular Histology·Lawrence OwusuXin Yi

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