A comparison of the skeletal neuromuscular and autonomic ganglion-blocking potencies of five non-depolarizing relaxants

British Journal of Pharmacology
A T Birmingham, S Z Hussain

Abstract

1 Results from in vitro experiments on the phrenic nerve-diaphragm and the hypogastric nerve-vas deferens preparations of the guinea-pig have been used to plot log concentration-effect curves for skeletal neuromuscular and ganglion blockade, respectively, for (+)-tubocurarine, pancuronium, alcuronium, gallamine and fazadinium (AH 8165). 2 From the log concentration-effect curves, EC50S and equipotent ratios were calculated. The order of neuromuscular blocking potency was pancuronium = alcuronium > (+)-tubocurarine > fazadinium = gallamine. The ratio EC50 for ganglion blockade/EC50 for neuromuscular blockade was 2.3 for fazadinium, 6.7 for (+)-tubocurarine, 22.9 for alcuronium, 24.3 for gallamine and 200.0 for pancuronium. 3 For pancuronium and gallamine there was a range of concentrations below those producing ganglion blockade at which the response of the vas deferens to hypogastric nerve stimulation was augmented. 4 The results are compared with some of those available in the literature, measured on other species by other methods.

References

Nov 1, 1975·The Journal of Pharmacy and Pharmacology·A D IvankovichB Zahed
Aug 1, 1979·Acta Anaesthesiologica Scandinavica·S Z HussainA T Birmingham
Nov 1, 1976·British Journal of Pharmacology·A L Clark, F Mitchelson
Mar 1, 1968·British Journal of Pharmacology and Chemotherapy·W R BuckettM B Morton
Jan 1, 1969·Acta Anaesthesiologica Scandinavica. Supplementum·I Lund, J Stovner
Aug 1, 1973·British Journal of Anaesthesia·R T Brittain, M B Tyers
Apr 1, 1971·British Journal of Anaesthesia·G R Kelman, B R Kennedy
Jun 1, 1970·Proceedings of the Society for Experimental Biology and Medicine·D J MiletichT A Strike
Oct 1, 1968·British Journal of Anaesthesia·B R Kennedy, J V Farman
Mar 6, 1967·JAMA : the Journal of the American Medical Association·N T Smith, C E Whitcher
Apr 1, 1961·British Journal of Pharmacology and Chemotherapy·S HUKOVIC
Aug 1, 1963·British Journal of Pharmacology and Chemotherapy·G A BENTLEY, J R SABINE
Dec 1, 1963·British Journal of Pharmacology and Chemotherapy·A T BIRMINGHAM, A B WILSON
Mar 1, 1946·British Journal of Pharmacology and Chemotherapy·E BULBRING

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