A comparison of the suppressive effects of testosterone and a potent new gonadotropin-releasing hormone antagonist on gonadotropin and inhibin levels in normal men

The Journal of Clinical Endocrinology and Metabolism
C J BagatellW J Bremner

Abstract

GnRH antagonists have been developed in large part because of their potential use as contraceptive agents, particularly in men. Specifically, it was hoped that GnRH antagonists combined with testosterone (T) would be a more effective contraceptive regimen than T alone. We compared the suppressive effects of a potent GnRH antagonist, Na1-Glu [AcD2NaL1,D4ClPhe2,D3Pal3,Arg5,DGlu6(AA),+ ++DAla10-GnRH], and of T together and separately on serum and urinary gonadotropin and serum inhibin levels in normal men. Ten-day courses of Nal-Glu (75 micrograms/kg; Nal-Glu alone), 200 mg testosterone enanthate, im, on days 0 and 7 (T alone), and the combination (Na1-Glu + T) were given to nine men. Serum gonadotropin and inhibin concentrations decreased after 1-2 days of Na1-Glu administration, while gonadotropin suppression occurred more slowly after T alone. Serum T fell to 30% of baseline values during Na1-Glu administration. The combination of Na1-Glu + T was more effective in suppressing serum LH, FSH, and inhibin than was either Na1-Glu alone or T alone. All hormone levels returned to baseline levels within 2.5 weeks after the end of the three regimens. We conclude that the Na1-Glu GnRH antagonist effectively inhibits gonadotropin, inhibi...Continue Reading

Citations

Sep 1, 1991·Medicinal Research Reviews·S RayA Kumar
Dec 3, 2003·Current Opinion in Pharmacology·Karen L Herbst
Apr 1, 1992·Baillière's Clinical Endocrinology and Metabolism·D M RobertsonD M de Kretser
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Dec 1, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·C Oxynos, F C Wu
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Jul 11, 2002·The Journal of Clinical Endocrinology and Metabolism·Karen L HerbstWilliam J Bremner
Jul 1, 1990·Journal of Endocrinological Investigation·D M de KretserG P Risbridger

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