A comparison of the tumour concentrations obtainable with misonidazole and Ro 03-8799

The British Journal of Radiology
S DischeP Wardman

Abstract

Both Ro 03-8799 and misonidazole were administered to six patients before tumour sampling. Using similar doses, tumour concentrations of Ro 03-8799 were approximately double those of misonidazole. Examination of the data with regard to the relative sensitising efficiencies of these two compounds gives us, as a conservative estimate, a factor of 1.6 in favour of Ro 03-8799. From these observations it is predicted that, when given with radiotherapy in a 25-fraction course Ro 03-8799, is likely to be at least five times more effective as a hypoxic cell sensitiser than misonidazole.

References

Feb 1, 1979·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·G E AdamsC E Smithen
May 1, 1977·British Journal of Cancer·S DischeI R Flockhart
Jun 1, 1985·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·M F DennisM E Watts
Mar 1, 1981·British Journal of Cancer·S DischeA I Minchinton

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Citations

Jul 1, 1990·The British Journal of Radiology·M GuichardJ M Richard
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·S W YoungR A Miller
Apr 1, 1988·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J WallingM A Stephens
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·M R StratfordM Woodcock
Jul 1, 1986·International Journal of Radiation Oncology, Biology, Physics·S DischeR A Orchard
May 1, 1990·International Journal of Radiation Oncology, Biology, Physics·T S MaughanP Workman
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·F LespinasseM Guichard
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·P Workman
Nov 1, 1988·International Journal of Radiation Oncology, Biology, Physics·H F NewmanN M Bleehen
Jan 1, 1991·Cancer Chemotherapy and Pharmacology·P WorkmanC E Smithen
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·S DischeP Wardman
Apr 1, 1989·International Journal of Radiation Oncology, Biology, Physics·W G DeGraffJ B Mitchell

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