PMID: 8592098Jan 1, 1996Paper

A comparison of the urinary excretion of bone resorptive products in white and black children

The Journal of Laboratory and Clinical Medicine
J Howard PrattM Peacock

Abstract

Bone density is greater in blacks than in whites regardless of age. In adults, bone formation was shown previously to be much lower in blacks than in whites. A lower bone turnover in adult blacks may preserve a high bone density acquired earlier in life. Whether there is a difference in bone turnover in blacks and whites early in life is not known. Bone resorption is known to parallel bone formation, and thus in the present study we looked for racial differences in bone turnover in children by measuring the nocturnal urinary excretion of three markers of bone resorption: hydroxyproline and the pyridinium cross-links, pyridinoline and deoxypyridinoline. Sixty-four black and 145 white children ages 6 through 15 years were studied. We found excretion of hydroxyproline to be similar in whites and blacks. Urinary excretion of the cross-links was about 10% to 15% lower in blacks, but only the excretion of pyridinoline in boys was significantly lower in blacks (p = 0.031). Overnight urinary calcium excretion was about 30% lower in blacks than in whites (p = 0.0016 for boys and p = 0.008 for girls), as has been reported previously by others. In summary, the excretion rates of bone resorptive products in white and black children were si...Continue Reading

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Citations

Oct 25, 2012·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·S J WardenR D Lewis
Feb 12, 2013·Current Hypertension Reports·Wanzhu Tu, J Howard Pratt
Mar 23, 1999·Archives of Disease in Childhood·S M HusainW D Fraser
Mar 6, 2009·American Journal of Physiology. Renal Physiology·Tao NaJi-Bin Peng
Dec 11, 2008·The Journal of Clinical Endocrinology and Metabolism·Jeesun JungJ Howard Pratt
Apr 3, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K O O'BrienR F Gagel
Apr 7, 2015·The Journal of Pediatrics·Lynae J HanksKrista Casazza
Jan 9, 2014·Annals of Clinical Biochemistry·Thinn Thinn Hlaing, Juliet E Compston
Jul 9, 2008·Hypertension·Tae-Yon ChunJ Howard Pratt
Sep 5, 2014·American Journal of Physiology. Renal Physiology·Hayo Castrop, Ina Maria Schießl
Oct 26, 2018·Physiological Reviews·Agustin Gonzalez-VicenteJeffrey L Garvin
Feb 6, 2002·Medicine and Science in Sports and Exercise·Henrikas VaitkeviciusWarren Lockette
May 20, 2021·Journal of Orthopaedic Surgery and Research·Filippo MiglioriniGiorgino Riccardo
Jun 2, 2021·Journal of Orthopaedic Surgery and Research·Filippo MiglioriniRiccardo Giorgino

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