A comparison of the use of cephalothin and oxacillin in vascular surgery

Archives of Surgery
A R MayC S Darling

Abstract

A randomized trial comparing two prophylactic antibiotics in vascular surgery was reviewed retrospectively. Two hundred thirty-two patients were given cephalothin sodium, and 168 patients were given oxacillin sodium. The overall incidence of wound infection was 1.5%; there was only one prosthetic graft infection in 346 patients in whom prosthetic material was used. There was no significant difference in wound infection between the groups. When postoperative infection in other areas was considered, however, it appeared that cephalothin was a more suitable antibiotic for treatment of these infections despite its use prophylactically. Although this trial was uncontrolled, the low overall incidence of wound and graft infection would appear to support the use of prophylactic antibiotics in vascular surgery.

Citations

Apr 1, 1996·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·M D'AddatoA Freyrie
Nov 1, 1980·World Journal of Surgery·R C Darling, D C Brewster
Jan 1, 1991·Infection·D H Wittmann, R E Condon
Dec 1, 1991·Current Problems in Surgery·R E Condon, D H Wittmann
Jul 4, 2007·Journal of Vascular Surgery·Andrew H StewartJonothan J Earnshaw
Feb 19, 1998·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M D'AddatoA Freyrie
Oct 30, 1986·The New England Journal of Medicine·A B Kaiser
Jul 21, 2006·The Cochrane Database of Systematic Reviews·A StewartJ J Earnshaw

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