PMID: 9648969Jul 2, 1998Paper

A comparison of three methods of measuring 99mTc-DTPA lung clearance and their repeatability

The European Respiratory Journal
D MorrisonW MacNee

Abstract

The lung clearance of technetium-99m diethylenetriamine penta-acetic acid (99mTc-DTPA) is a measure of respiratory epithelial permeability. Many factors may contribute to the wide range of normal values, including the method of correction for background activity. The aim of this study was to compare three methods of analysis, including their repeatability. 99mTc-DTPA lung clearance imaging was performed on eight nonsmokers (age 32+/-2 yrs, forced expiratory volume in one second (FEV1) 102.8+/-3.3% predicted yrs, mean+/-SEM and seven smokers (age 46+/-4 yrs, p<0.01, versus nonsmokers; FEV1 88.9+/-8.9%, p<0.05 versus nonsmokers) on two occasions each. The smokers were asked to refrain from smoking for 12 h. An uncorrected analysis was compared with two methods corrected for recirculating background activity using an intravenous correction and inter-renal and shoulder background regions of interest. The uncorrected method gave higher mean values for 50% lung clearance of 99mTc-DTPA (t50) values than the inter-renal (p<0.001) and shoulder (p<0.001) methods of correction in nonsmokers and the inter-renal method gave lower values than the shoulder-corrected method (p<0.05). In smokers there was no difference. There were no difference...Continue Reading

Citations

Jun 12, 2009·Annals of Nuclear Medicine·Ujwal N BhureA J Paidhungat
Jul 30, 2004·Thorax·H van der VaartN H T ten Hacken
Feb 2, 1999·American Journal of Respiratory and Critical Care Medicine·D MorrisonW MacNee
Jun 19, 2002·American Journal of Respiratory and Critical Care Medicine·William D Bennett

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