PMID: 8938036Nov 1, 1996Paper

A comparison of time-domain and frequency-domain approaches to ultrasonic velocity measurement in trabecular bone

Physics in Medicine and Biology
P H NicholsonG Van der Perre

Abstract

Different methods for ultrasonic velocity determination using broad-band pulse transmission have been investigated in 70 human calcanae in vitro. The work took place within the context of the EC BIOMED1 concerted action Assessment of Quality of Bone in Osteoporosis. Ultrasonic velocities were determined using three different transit time definitions: first arrival (TTV1), thresholding (TTV2), and first zero crossing (TTV3). Phase velocity (PV) was determined over a range of frequencies from 200 to 800 kHz using a new phase spectral analysis technique. The different velocity measurements were compared in terms of their magnitudes and their inter-correlations. There were significant differences of up to 260 m s-1 between different transit time velocities (p < 0.0001), indicating the sensitivity of the measurement to the arrival criteria used. Phase velocities were lower than all of the transit time velocities (p < 0.0001) and decreased with increasing frequency (p < 0.005). A strong correlation (r2 = 0.968) was observed between PV at 400 kHz (PV400) and TTV3, with much weaker correlations between PV and the other transit time velocities. Reproducibility for transit time velocity measurement was optimal for TTV3 (coefficient of va...Continue Reading

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