PMID: 9425382Jan 13, 1998Paper

A comparison of two amikacin dosing regimens in paediatric surgical patients

Annals of Tropical Paediatrics
N B ForsythG P Hadley

Abstract

This investigation aimed to compare the efficacy and toxicity of two amikacin dosing regimens in seriously ill paediatric surgical patients. Children (0.6-12 years old) received amikacin intravenously either once daily (15 mg/kg, n = 27) or twice daily (7.5 mg/kg, n = 27). Concomitant medication was given as prescribed. Mean (SD) peak serum amikacin levels were significantly different (p < 0.05) between the once and twice daily groups (37.7 (6.9) mg/l and 19.5 (3.7) mg/l, respectively). Cumulative dose and duration of therapy were also significantly higher in the once-daily group. Regimen efficacy (favourable, unfavourable or indeterminate outcome) was assessed by patient temperatures, clinical improvement and white cell counts. Serum creatinine measurements and post-therapy, pure tone air conduction audiometry assessed nephro- and ototoxicity, respectively. No statistically significant differences were found between the groups in terms of outcome (18/24 and 22/25 patients in the once- and twice-daily groups had favourable outcomes; there were no unfavourable outcomes), nephrotoxicity (none of the patients assessed developed nephrotoxicity) or ototoxicity (2/20 and 5/20 patients, respectively, had mild high frequency hearing de...Continue Reading

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Citations

Apr 21, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·S FreemanH Sohmer

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