A comparison of two long-acting vasoselective calcium antagonists in pulmonary hypertension secondary to COPD

Chest
D SajkovR D McEvoy

Abstract

STUDY OBJECTIVES AND PATIENTS: Pulmonary hypertension (PH) is common in COPD and may predict mortality in this disorder. We have compared the pulmonary vasodilator effects, dose-response characteristics, and tolerability of two calcium channel blockers, amlodipine and extended-release (ER) felodipine, in 10 patients (seven men, age 68+/-4.8 [SD] years) with clinically stable COPD and PH. Drugs were given in equal single daily oral doses (2.5, 5, and 10 mg), increasing weekly for 3 weeks, in a randomized investigator-blinded crossover manner with a 1-week wash-out period between the two treatments. Doppler measurements of pulmonary hemodynamics were made on the seventh day of treatment at each drug dose. Lung function, arterial blood gases, and adverse events were also monitored weekly. A dose-dependent decline of pulmonary artery pressure (PAP) was observed with each drug. A dose of 2.5 mg produced a significant decrease in PAP compared with baseline (20% amlodipine, 17% felodipine ER). Additional decreases in PAP were observed at 5 mg and 10 mg that were similar for both drugs, but did not reach statistical significance compared with 2.5 mg. There was a dose-related decrease in pulmonary vascular resistance and increase in oxy...Continue Reading

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Citations

Mar 19, 2002·Respirology : Official Journal of the Asian Pacific Society of Respirology·Wataru HidaKunio Shirato
Apr 17, 2010·Cardiology in Review·Joe R Anderson, James J Nawarskas
Mar 20, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Ian Adatia, Lara Shekerdemian
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Desuo Wang, Xiangli Cui
Aug 29, 2014·BioMed Research International·Amirmasoud ZangiabadiDimitar Sajkov
Sep 20, 2015·American Heart Journal·Kishan S ParikhZainab Samad
Feb 11, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Javed ButlerJohn R Wilson
Jul 21, 2001·Journal of Human Hypertension·N A Chung, G Y Lip

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