A comparison of two methods for estimating 50% of the maximal motor evoked potential

Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology
Julia B PitcherMichael C Ridding

Abstract

Two commonly-used methods for setting stimulus intensities in transcranial magnetic brain stimulation studies were compared to determine which best approximated a motor evoked potential (MEP) of 50% of the maximal MEP amplitude (SI50); a suprathreshold intensity relative to resting motor threshold (rMT) or adjusting the intensity to evoke an MEP amplitude of 1mV. Corticomotor stimulus-response curves and rMT for the right first dorsal interosseous (FDI) muscle of 176 subjects (aged 10-74 years) were retrospectively analysed. Regardless of subject age or sex, SI50 occurred at 127.5 ± 11.3% rMT. Except in young children, MEPs of 1 mV were significantly smaller than those evoked at SI50. In the inactive FDI muscle, a stimulus intensity of 127-128% rMT consistently gives the best approximation of SI50 in most subjects, except perhaps young children. Setting TMS stimulus intensities relative to rMT provides a less variable inter-subject comparator, with respect to individual differences in corticomotor input-output characteristics, than adjusting the stimulator output to give an absolute MEP magnitude.

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Citations

Jul 1, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mitchell R GoldsworthyMichael C Ridding
May 15, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·A J YarnallM R Baker
Feb 24, 2016·The European Journal of Neuroscience·Pattamon PanyakaewMark Hallett
Oct 29, 2015·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·L A SchneiderJ B Pitcher
May 13, 2017·Journal of Applied Physiology·Hamidollah HassanloueiSandra K Hunter
Jan 9, 2017·Brain Structure & Function·Antonino NaroRocco Salvatore Calabrò
Sep 26, 2020·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jesminne CastricumYpe Elgersma
Aug 5, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Daniel T CorpUNKNOWN 'Big TMS Data Collaboration'

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