A comparison of two methods for measuring airway distensibility: nitrogen washout and the forced oscillation technique

Physiological Measurement
Nathan J BrownGregory G King

Abstract

The measurement of airway stiffness is an important tool for studying airway remodelling in asthma. The relationship between airway calibre and lung volume (airway distensibility) was measured by forced oscillation technique (FOT) and compared with that measured by single-breath nitrogen washout (SBNW). In four non-asthmatic healthy subjects and three asthmatics, anatomical dead space (VDF) was measured by SBNW and respiratory system conductance (Grs) was measured by FOT at 6 Hz. During SBNW testing, 0.51 oxygen boluses were inhaled from three different lung volumes: functional residual capacity (FRC), 11 above FRC and near total lung capacity (TLC). Following inhalation of the oxygen bolus subjects exhaled to residual volume and then inhaled to TLC. During FOT, subjects breathed 0.5-1.01 tidal volumes but with gradually increasing end-expiratory lung volume until close to TLC, then returned to normal breathing before inhaling to TLC. This was also repeated but with reducing lung volume from TLC. Absolute lung volumes were measured by body plethysmography and related to volumes during FOT and SBNW by reference to TLC obtained at the end of each SBNW or FOT test manoeuvre. Distensibility was calculated as the linear regression s...Continue Reading

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Citations

Apr 28, 2007·American Journal of Respiratory and Critical Care Medicine·Nathan J BrownGregory G King
Jul 19, 2011·Respiratory Research·Nancy T MendonçaKenneth R Lutchen
Oct 5, 2013·Chest·Florian SingerPhilipp Latzin
Aug 30, 2005·Respiratory Physiology & Neurobiology·Walid HabreFerenc Peták
Feb 16, 2011·Respiratory Physiology & Neurobiology·Paul D RobinsonGreg G King
Feb 1, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Ynuk Bossé

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