PMID: 2124750Nov 1, 1990Paper

A comparison of xylazine-diazepam-ketamine and xylazine-guaifenesin-ketamine in equine anesthesia

Veterinary Surgery : VS
N Brock, S V Hildebrand

Abstract

After sedation with xylazine (0.3 mg/kg intravenously [IV]), anesthesia was induced in six healthy horses with ketamine (2.0 mg/kg IV) and guaifenesin (100 mg/kg IV), diazepam (0.05 mg/kg IV), or diazepam (0.10 mg/kg IV). Anesthesia was maintained with halothane for 30 minutes. Heart rate, respiratory rate, direct arterial blood pressure, arterial blood gas, and pH measurements were made before, and at set intervals after, induction of anesthesia. Quality and characteristics of induction and recovery were evaluated objectively by an independent observer unaware of the protocol used. There were no significant differences among the three protocols from pre-induction values for arterial blood pressure, blood gas values, and pH. There was significantly greater ataxia at induction with the use of guaifenesin. The nature of induction, transition to and recovery from general anesthesia were comparable between guaifenesin and the higher dose of diazepam. Because of movements and difficulty with intubation, the lower dose of diazepam was considered unsatisfactory. It was concluded that diazepam (0.10 mg/kg) could be substituted for guaifenesin (100 mg/kg) to produce comparable quality of anesthesia in horses.

Citations

Mar 16, 2013·Equine Veterinary Journal·J A E HubbellJ Lakritz
Mar 29, 2012·American Journal of Veterinary Research·John A E HubbellRichard M Bednarski
Jul 1, 1992·Veterinary Surgery : VS·P Y WanP O Mueller
Jul 3, 2021·Animals : an Open Access Journal From MDPI·Miguel Gozalo-Marcilla, Simone Katja Ringer
Apr 6, 2004·The Veterinary Clinics of North America. Equine Practice·Janyce Cornick-Seahorn
Jun 15, 2007·Veterinary Anaesthesia and Analgesia·Renata B RossettiRodrigo S Ferreira da Cruz

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