A comparison study on the release kinetics and mechanism of bovine serum albumin and nanoencapsulated albumin from hydrogel networks.

International Journal of Biological Macromolecules
Kaixi ChenYao Fu

Abstract

An in situ-forming biodegradable hydrogel network has been developed to achieve extended release of protein drugs. Hyaluronic acids (HA) were selected as the scaffolding materials, and modified to afford thiolated HA (HASH) and methacrylated HA (HAME). Under near physiological conditions, a mixture of HASH and HAME achieved efficient sol-gel transition within 10 min at 37 °C. A systematic study was performed to characterize the morphology, rheological properties, swelling, degradation, and biocompatibility of the obtained hydrogel networks. Next, bovine serum albumin (BSA) and its nanocapsules were entrapped in the hydrogel network. Standard in vitro release studies and mathematic modeling were performed to gain insights into the release kinetics and mechanisms of protein drugs from the hydrogel network. For the hydrogel-nanocapsule hybrid system, a mathematical model combining the release processes from nanocapsules and hydrogel networks has been proposed to describe the release behavior of BSA from nanocapsules entrapped in the hydrogel network.

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