A comparison using quantitative enzyme cytochemistry between leucocyte alkaline phosphatase levels in the bone marrow and blood of the rat

British Journal of Haematology
D M WilliamsD J Evans


Leucocyte alkaline phosphatase (LAP) levels have been compared in neutrophil polymorphs in bone marrow and blood in the rat, using a quantitative enzyme cytochemical technique. It has been shown that LAP levels are higher in bone marrow than blood, both in normal animals and those with experimentally-induced local inflammatory lesions. In the latter group both marrow and blood LAP levels were higher than in controls; blood levels rose because of the outpouring of cells with moderately high LAP levels into the blood and marrow levels rose because only cells with very high LAP levels remained. The inverse relationship between neutrophil age and alkaline phosphatase content, previously demonstrated in the peripheral blood of the rat, has also been shown to exist in the bone marrow.


Jan 1, 1976·International Review of Cytology·J Breton-Gorius, F Reyes
Jun 1, 1974·British Journal of Haematology·A J Altman, T P Stossel
Dec 1, 1967·The Journal of Clinical Investigation·J C MarshM M Wintrobe
Oct 13, 1958·Annals of the New York Academy of Sciences·W C MOLONEY
Jun 1, 1959·American Journal of Clinical Pathology·S TRUBOWITZV M HUNT

Related Concepts

Alkaline Phosphatase
Differential White Blood Cell Count Procedure
Neutrophil Band Cells
Rats, Laboratory

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