PMID: 15359568Sep 14, 2004Paper

A compartment model for the membrane-coated fiber technique used for determining the absorption parameters of chemicals into lipophilic membranes

Pharmaceutical Research
Xin-Rui XiaJim E Riviere

Abstract

The purpose of this work was to develop a compartment model for the membrane-coated fiber (MCF) technique for determining the absorption parameters of chemicals into lipophilic membranes. A polymer membrane coated onto a section of inert fiber was used as a permeation membrane in the MCF technique. When MCFs were immersed into a donor solution, the compounds in the solution partitioned into the membrane. At a given permeation time, a fiber was removed from the solution and transferred into a gas chromatography injector for quantitative analysis. The permeation process of a given chemical from the donor phase into the membrane was described by a one-compartment model by assuming first-order kinetics. A mathematical model was obtained that describes the cumulative amount of a chemical permeated into the membrane as a function of the permeation time in an exponential equation. Two constants were introduced into the compartment model that were clearly defined by the physiochemical parameters of the system (a kinetic parameter and the equilibrium absorption amount) and were obtained by regression of the experimental data sampled over a limited time before equilibrium. The model adequately described the permeation kinetics of the MCF...Continue Reading

Citations

Dec 9, 2008·SAR and QSAR in Environmental Research·R E BaynesJ E Riviere
Apr 15, 2010·Journal of Toxicology and Environmental Health. Part a·Jim E RiviereElisha L Koivisto
Apr 18, 2013·Cutaneous and Ocular Toxicology·Daniela Karadzovska, Jim Riviere

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