A compartmental model for biokinetics and dosimetry of 18F-choline in prostate cancer patients

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
Augusto GiussaniMarie-Claire Cantone

Abstract

PET with (18)F-choline ((18)F-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skåne University Hospital Malmö were used for the development of a biokinetic and dosimetric model. The biodistribution of (18)F-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentrations in blood and urine samples were also determined. A compartmental model structure was developed, and values of the model parameters were obtained for each single patient and for a reference patient using a population kinetic approach. Radiation doses to the organs were determined using computational (voxel) phantoms for the determination of the S factors. The model structure consists of a central exchange compartment (blood), 2 compartments each for the liver and kidneys, 1 for spleen, 1 for urinary bladder, and 1 generic compartment accounting for the remaining material. The model can successfully describe the individual patients' data. The parameters showing the greatest interindividual variations are the blood volume (the clearance process is rapid, and early blood data are not available for several patients) and the transfer out from li...Continue Reading

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Citations

Jul 23, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Paolo Zanotti-FregonaraRobert B Innis
Oct 3, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Axel WetterJames Nagarajah
Mar 19, 2013·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·F ZagniM Marengo
Nov 6, 2014·Medical Physics·Tzu-Cheng LeeYoungho Seo
Nov 19, 2013·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Cinzia FabbriFederica Matteucci
May 22, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Christian H PfobMatthias Eiber
Aug 12, 2016·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Marina B SilveiraMarcelo Mamede
Feb 3, 2016·Radiology and Oncology·Sebastijan RepMarko Hocevar
Jan 27, 2018·European Radiology·G F HuberG K von Schulthess
Jan 7, 2016·Physics in Medicine and Biology·Jesús Silva-RodríguezPablo Aguiar
Jan 8, 2015·Physics in Medicine and Biology·Harrison H BarrettMark P Little
Oct 21, 2016·Physics in Medicine and Biology·Alexandra ZverevaMarkus Schwaiger

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