PMID: 9174477Jun 1, 1997Paper

A compartmental model of zinc metabolism in healthy women using oral and intravenous stable isotope tracers

The American Journal of Clinical Nutrition
N M LoweJ C King

Abstract

A mathematical model of zinc metabolism in six healthy women (average age: 30 +/- 11 y) was developed by using stable isotopes of zinc. After equilibration on a constant diet containing 7.0 mg Zn/d, an oral tracer highly enriched in 67Zn and an intravenous tracer highly enriched in 70Zn were administered simultaneously. Multiple plasma and 24-h urine samples were collected for the next 7 d with complete fecal collections for 11 d. Tracer-trace ratios in plasma, urine, and feces were calculated from isotope ratios of 67Zn to 66Zn and 70Zn to 66Zn measured by using inductively coupled plasma-mass spectrometry. An a priori identifiable model composed of seven compartments was developed to describe the kinetics of both tracers as well as that of naturally occurring zinc. The parameters of the model were fitted to the data by using the SAAM-CONSAM modeling software and were estimated with good precision. Several important, not directly measurable zinc variables were estimated (mean +/- SEM) from the model including the fractional absorption from the gastrointestinal tract (0.279 +/- 0.043), the rates of endogenous secretion (2.79 +/- 0.49 mg/d) and excretion (2.01 +/- 0.35 mg/d), the fractional turnover rate of the plasma pool (131 ...Continue Reading

Citations

Dec 3, 1999·The American Journal of Clinical Nutrition·S A Abrams
Feb 7, 2001·The American Journal of Clinical Nutrition·J R DaintyS J Fairweather-Tait
Jun 1, 2001·The Journal of Nutrition·D M ShamesJ C King
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Giovanni SparacinoClaudio Cobelli
Feb 2, 2002·The Journal of Nutrition·Michael HambidgeGary Grunwald
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May 6, 2003·The Journal of Nutrition·Nancy F KrebsGary Grunwald
Jul 9, 2005·The American Journal of Clinical Nutrition·Christine Feillet-CoudrayCharles Coudray
Jul 9, 2005·The American Journal of Clinical Nutrition·Carmen M DonangeloJanet C King
Nov 9, 2007·Food and Nutrition Bulletin·Christine Hotz
Apr 15, 2008·Journal of Pediatric Endocrinology & Metabolism : JPEM·Gianna ToffoloAgneta L Sunehag
Feb 20, 2009·Annals of Biomedical Engineering·Barbara JuilletHélène Fouillet
Mar 9, 2019·Metallomics : Integrated Biometal Science·Klervia JaouenFrancis Albarède
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Jul 28, 2004·The American Journal of Clinical Nutrition·Ian J GriffinSteven A Abrams
Jul 14, 2001·The American Journal of Clinical Nutrition·J C KingM J Jackson
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Nov 20, 2012·Food and Nutrition Bulletin·Vani AmalrajanAnura Kurpad
Apr 16, 2019·Annual Review of Nutrition·Janet C King
Jul 5, 2002·The Journal of Nutrition·Carmen M DonangeloJanet C King
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May 31, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Magalie SabatierJudith R Turnlund
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Jan 9, 2007·The American Journal of Clinical Nutrition·Linda J HarveySusan J Fairweather-Tait
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Jun 8, 2004·Pediatric Research·Ian J GriffinSteven A Abrams
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Aug 18, 2004·Journal of the American College of Nutrition·Jihye KimJanet C King
May 10, 2000·The Journal of Nutrition·M E WastneyK N Subramanian

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