A competent bidrug loaded water soluble chitosan derivative for the effective inhibition of breast cancer.

Scientific Reports
Nivethaa E A KNarayana Kalkura S

Abstract

Drug resistance and damage caused to the normal cells are the drawbacks which have limited the use of the existing effective anticancer drugs. Attainment of a steady and extended release by encapsulating dual drugs into biocompatible and biodegradable vehicles is the key to enable the use of these drugs for effective inhibition of cancer. In this study, carboxymethyl chitosan (CMCS), a proficient water-soluble derivative of chitosan has been synthesized using chemical route and used for the delivery of 5-Fluorouracil and doxorubicin individually as well as in combination. Carboxymethylation occuring at -NH2 and OH sites of chitosan, has been confirmed using FTIR. EDX and Fluorescence studies elucidate the encapsulation of 5-Fluorouracil and doxorubicin into CMCS. The capability of CMCS to release the drugs in a more sustained and prolonged manner is evident from the obtained release profiles. About 14.9 µg/ml is enough to cause 50% cell death by creating oxidative stress and effectuating DNA fragmentation. Amidst the existing reports, the uniqueness of this work lies in using this rare coalition of drugs for the suppression of breast cancer and in reducing the side effects of drugs by encapsulating them into CMCS, which is evid...Continue Reading

References

Jun 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A P VenookC D Jacobs
Feb 1, 1983·European Journal of Cancer & Clinical Oncology·A CoatesM H Tattersall
May 2, 2003·Nature Reviews. Cancer·Daniel B LongleyPatrick G Johnston
Jun 5, 2004·International Journal of Biological Macromolecules·Laura B TalaricoElsa B Damonte
Jan 25, 2008·Biopharmaceutics & Drug Disposition·Ya-Ni DaiQin Wei
Apr 20, 2010·International Journal of Cardiology·Jean-Jacques MonsuezJean-Yves Artigou
Feb 8, 2011·CA: a Cancer Journal for Clinicians·Ahmedin JemalDavid Forman
Mar 11, 2011·Cell Death & Disease·L-U LingG N C Chiu
Jun 10, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jonghoon ChoiRichard A Malinauskas
Dec 25, 2012·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Reem K Farag, Riham R Mohamed
Jan 12, 2013·Biomacromolecules·Sriwanna SanyakamdhornHeidar-Ali Tajmir-Riahi
May 13, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A AnithaR Jayakumar
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jan 19, 2016·International Journal of Biological Macromolecules·Andrea L BukzemDiego Palmiro R Ascheri
Mar 19, 2016·The Journal of Pharmacy and Pharmacology·Ann-Marie Meredith, Crispin R Dass
May 22, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Nivethaa E A KStephen A
Nov 5, 2016·International Journal of Biological Macromolecules·Nivethaa E A KStephen A
Mar 5, 2017·Colloids and Surfaces. B, Biointerfaces·Simo KalliolaMika Sillanpää
Apr 9, 2017·Journal of Photochemistry and Photobiology. B, Biology·Sunil ShahIgnacy Gryczynski
Jun 8, 2017·Oncology Letters·Isaac KimKyung-Soon Park
Feb 15, 2018·Scientific Reports·Muhammad U FarooqZhiming Wang
Oct 4, 2018·International Journal of Biological Macromolecules·Ezzeddin M A HejjajiGordon A Morris
Nov 23, 2018·International Journal of Nanomedicine·Tugba YildizTania Betancourt
Dec 18, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kevin LingJulie A Champion
Jun 28, 2019·The Journal of Physical Chemistry. B·Baskar SrinivasanSubbaraya Narayana Kalkura
Dec 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Lidi ChenFaquan Yu

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Methods Mentioned

BETA
Fluorescence
dynamic light scattering
Electrophoresis
PCR
X-ray
ELISA

Software Mentioned

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