PMID: 9546168Apr 18, 1998Paper

A competitive microflora increases the resistance of Salmonella typhimurium to inimical processes: evidence for a suicide response

Applied and Environmental Microbiology
Timothy G AldsworthG S Stewart

Abstract

The presence of a viable competitive microflora at cell densities of 10(8) CFU ml-1 protects an underlying population of 10(5) CFU of Salmonella typhimurium ml-1 against freeze injury. The mechanism of enhanced resistance was initially postulated to be via an RpoS-mediated adaptive response. By using an spvRA:: luxCDABE reporter we have shown that although the onset of RpoS-mediated gene expression was brought forward by the addition of a competitive microflora, the time taken for induction was measured in hours. Since the protective effect of a competitive microflora is essentially instantaneous, the stationary-phase adaptive response is excluded as the physiological mechanism. The only instantaneous effect of the competitive microflora was a reduction in the percent saturation of oxygen from 100% to less than 10%. For both mild heat treatment (55 degrees C) and freeze injury this change in oxygen tension affords Salmonella a substantive (2 orders of magnitude) enhancement in survival. By reducing the levels of dissolved oxygen through active respiration, a competitive microflora reduces oxidative damage to exponential-phase cells irrespective of the inimical treatment. These results have led us to propose a suicide hypothesis...Continue Reading

References

Jan 1, 1992·Journal of Bacteriology·D A Siegele, R Kolter
Apr 1, 1991·International Journal of Food Microbiology·A EllisonG S Stewart
Sep 1, 1984·Applied and Environmental Microbiology·D A Schiemann, S A Olson
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Jan 1, 1996·Journal of Bacteriology·T SchwederA Matin

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Citations

Jan 16, 2004·Journal of Applied Microbiology·E KomitopoulouM R Adams
Jun 14, 2000·Journal of Food Protection·M E Doyle, A S Mazzotta
May 5, 2005·Applied and Environmental Microbiology·Abram AertsenChris W Michiels
Sep 8, 2010·Applied and Environmental Microbiology·Guillermo CebriánSantiago Condón
Jul 4, 2012·Acta Microbiologica Et Immunologica Hungarica·Snezana Ivić-KolevskaBranislava Kocić
Jun 10, 2004·Journal of Applied Microbiology·P De SpiegeleerC W Michiels
Jan 14, 2005·Critical Reviews in Microbiology·Abram Aertsen, Chris W Michiels
Oct 8, 1999·Luminescence : the Journal of Biological and Chemical Luminescence·P Hill, P Stanley
Nov 25, 2021·Science Translational Medicine·Kohta SaitoCarl Nathan

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