A complete route for biodegradation of potentially carcinogenic cyanotoxin microcystin-LR in a novel indigenous bacterium

Water Research
Fei YangYuepu Pu

Abstract

Microcystin-leucine-arginine (MC-LR), a cyclic potentially carcinogenic hepatotoxin, occurs frequently in aquatic habitats worldwide and seriously threatens ecosystem and public health. Limited effectiveness of physicochemical treatments to remove MC-LR from drinking water has led to a search for alternative cost-effective and environment friendly biodegradation strategies. Obtaining MC-degrading bacteria and understanding their MC-degrading mechanisms are outstanding challenges. Here, a novel indigenous bacterium named Sphingopyxis sp. YF1 with a high efficient capacity for MC-degradation was successfully isolated from eutrophic Lake Taihu. Through integrating mass spectrometer and multi-omics analyses accompanied by functional verification of certain genes and proteins, a complete MC-degradation pathway was firstly identified, in which MC-LR was sequentially degraded into linearized MC-LR, tetrapeptide, Adda, phenylacetic acid, and finally potential product CO2. Some specific proteins such as microcystinase, linearized-microcystinase, tetrapeptidease and PAAase responsible for this pathway were identified. This study pioneeringly demonstrated that MC-LR can be completely degraded through natural remediation processes and reve...Continue Reading

Citations

Jan 17, 2020·Environmental Science and Pollution Research International·Guofeng RenFei Yang
Apr 25, 2020·Toxins·Isaac Yaw Massey, Fei Yang
Oct 7, 2020·Toxins·Isaac Yaw MasseyFei Yang
Nov 5, 2020·Toxins·Shuaishuai XuLi Tian
Sep 30, 2020·Environmental Research·Shiyu ZhangHuizhen Zhang
Feb 23, 2021·Environmental Research·Linjia ShiHuizhen Zhang
Apr 16, 2021·Environment International·Shuilin ZhengFei Yang
Jun 3, 2021·Environment International·Ya MaHuizhen Zhang
May 17, 2021·Toxicon : Official Journal of the International Society on Toxinology·Latife KökerMeriç Albay
Jul 5, 2021·Journal of Hazardous Materials·Kha Mong TranDokyun Na

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