PMID: 9438491Jan 23, 1998Paper

A complex of histamine/mouse gamma-globulin preferentially inhibits allergen-induced peritoneal accumulation of eosinophils, but not neutrophils, in mice

The Journal of Allergy and Clinical Immunology
H YoshiiH Okudaira

Abstract

A complex of histamine/human gamma-globulin (HhG) has been widely used in Japan for more than 25 years as a nonspecific hyposensitization drug in the treatment of allergic diseases. It has been reported that HhG decreases the number of eosinophils in the nasal secretions and peripheral blood of patients with allergy. In this study we used a mouse system to explore the possibility that HhG may actively inhibit the accumulation of eosinophils at inflammation sites. A complex of 0.15 microg of histamine dihydrochloride/12 mg of mouse gamma-globulin (HmG) was incubated for 2 hours in saline solution in the normal fashion for HhG. HmG at 50 to 150 mg/kg/day inhibited the peritoneal accumulation of eosinophils induced by ragweed pollen in BALB/c mice in a dose-dependent fashion when the HmG was administered subcutaneously six times during a 20-day sensitization period. The inhibitory effect of HmG on this eosinophil accumulation was significant at 24 and 48 hours after challenge, but HmG had no effect on neutrophil accumulation. Complexes of serotonin/mouse gamma-globulin (mgammaG), glutamine/mgammaG, and histamine dihydrochloride (His)/mouse albumin had no inhibitory effect when administered in the same way. The optimum combination ...Continue Reading

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Citations

Feb 13, 2008·International Archives of Allergy and Immunology·Dong-Ho NahmSook-Yeong Jeon
Jan 15, 2004·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T ShimizuH Shimizu
Jun 15, 2016·Indian Journal of Pharmacology·Gurumoorthy RajeshMurugan Venkatesan
Jan 26, 2021·Clinical Case Reports·Geunwoong Noh

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