A Complex Role for Calcium Signaling in Colorectal Cancer Development and Progression

Molecular Cancer Research : MCR
Wei WangYin Lu

Abstract

Clinical data suggest that many malignant cancers are associated with hypercalcemia. Hypercalcemia can facilitate the proliferation and metastasis of gastric and colon tumors, and has been considered a hallmark of end-stage disease. However, it has also been reported that dietary calcium or vitamin D supplementation could reduce the risk of many types of cancers. In particular, the intestines can absorb considerable amounts of calcium via Ca2+-permeable ion channels, and hypercalcemia is common in patients with colorectal cancer. Thus, this review considers the role of calcium signaling in the context of colorectal cancer and summarizes the functions of specific regulators of cellular calcium levels in the proliferation, invasion, metastasis, cell death, and drug resistance of colorectal cancer cells. The data reveal that even a slight upregulation of intracellular Ca2+ signaling can facilitate the onset and progression of colorectal cancer, while continuous Ca2+ influx and Ca2+ overload may cause tumor cell death. This dual function of Ca2+ signaling adds nuance to the debate over the hallmarks of colorectal cancer, and may even provide new directions and strategies for clinical interventions.

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Citations

Jan 21, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eva PeterovaDarina Kohoutova
Jun 3, 2021·International Journal of Molecular Sciences·Federica GaianiLuigi Laghi
Jun 16, 2021·World Journal of Surgical Oncology·Zhixiu XiaHong Zhang
Aug 31, 2021·Cancer Biomarkers : Section a of Disease Markers·Liming FanHong Ding

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