A composite of multisystem injury and neurocognitive impairment in HIV infection: association with everyday functioning

Journal of Neurovirology
María J MarquineR K Heaton

Abstract

The Veterans Aging Cohort Study (VACS) Index is a composite marker of multisystem injury among HIV-infected persons. We aimed to examine its cross-sectional association with functional outcomes, after considering neurocognitive impairment (NCI) and other well-established correlates of everyday functioning among HIV-infected persons. Participants included 670 HIV-infected adults (ages 18-76; 88% male; 63% non-Hispanic White; median current CD4 = 404 cells/mm3; 67% on antiretroviral therapy; AIDS = 63%) enrolled in observational studies at the University of California San Diego HIV Neurobehavioral Research Program. Functional outcomes were assessed via self-report measures of declines in activities of daily living, perceived cognitive symptoms in daily life, and employment status. NCI was assessed via a comprehensive neurocognitive test battery and defined based on established methods. Covariates examined included demographics, HIV disease characteristics not included in the VACS Index, and psychiatric comorbidities. The VACS Index was computed via standard methods and categorized based on its distribution. Results from multivariable regression models showed that both higher VACS Index scores (indicative of worse health) and the ...Continue Reading

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Citations

May 17, 2019·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Brian KavanaughKaren A Holler
Dec 27, 2019·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Brian C KavanaughAnthony Spirito
Sep 2, 2021·AIDS Research and Human Retroviruses·Celia Gabriela Hernández-FavelaJosé Alberto Avila-Funes
Sep 28, 2021·International Journal of STD & AIDS·Zaeema NaveedLorena Baccaglini

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Methods Mentioned

BETA
enzyme-linked immunosorbent assays
collection

Software Mentioned

JMP

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