A comprehensive analysis comparing the eighth AJCC gastric cancer pathological classification to the seventh, sixth, and fifth editions

Cancer Medicine
Sharvesh Raj SeeruttunZhiwei Zhou

Abstract

To perform a comprehensive analysis comparing the prognostic and discriminative ability of the eighth AJCC gastric cancer (GC) pathological classification to that of the seventh, sixth and fifth editions, and secondly to assess their long-term significance. Patients who had undergone R0 gastrectomy were identified and restaged accordingly. To evaluate and confirm any difference in prognostic ability between the competing editions, the Akaike information criterion (AIC) and Bayesian information criterion (BIC) were computed and compared since both have different analytic strengths. The area under the curve (AUC) with 95% CI based on the time-dependent receiver-operating characteristics analyses were also calculated to assess any change in prognostic rankings from the first to tenth postoperative year. The rankings calculated by both statistical methods showed similar results, in which the seventh edition was identified as possessing the best prognostic ability. Additionally, these ranks were found to remain consistent over the ten postoperative years, but demonstrated no clinical significance as their respective 95% CIs calculated by the AIC, BIC, and AUC were found to overlap. However, the more detailed staging classifications ...Continue Reading

References

Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Jan 20, 2011·Annals of Surgical Oncology·Miao-zhen QiuRui-hua Xu
Mar 2, 2011·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sumin ChaeJoo-Ho Lee
May 4, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Viktoria S WarnekeChristoph Röcken
Nov 1, 2011·Journal of the American College of Surgeons·Hong Man YoonYoung-Woo Kim
Nov 15, 2012·Annals of Surgical Oncology·Manali I PatelGeorge A Poultsides
Sep 16, 2014·International Journal of Cancer. Journal International Du Cancer·Jacques FerlayFreddie Bray
Jul 5, 2015·Journal of the American College of Surgeons·Daniele MarrelliUNKNOWN Italian Research Group for Gastric Cancer

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Methods Mentioned

BETA
surgical resection
dissection

Software Mentioned

SPSS
R

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