A comprehensive analysis of auditory event-related potentials and network oscillations in an NMDA receptor antagonist mouse model using a novel wireless recording technology

Physiological Reports
Niklas SchuelertHolger Rosenbrock

Abstract

There is growing evidence that impaired sensory processing significantly contributes to cognitive deficits found in schizophrenia. Electroencephalography (EEG) has become an important preclinical and clinical technique to investigate the underlying mechanisms of neurophysiological dysfunctions in psychiatric disorders. Patients with schizophrenia show marked deficits in auditory event-related potentials (ERP), the detection of deviant auditory stimuli (mismatch negativity, MMN), the generation and synchronization of 40 Hz gamma oscillations in response to steady-state auditory stimulation (ASSR) and reduced auditory-evoked oscillation in the gamma range. Due to a novel data-logging technology (Neurologger, TSE Systems), it is now possible to record wireless EEG data in awake, free-moving small rodents without any restrictions due to size of the device or attached cables. Recently, a new version of the Neurologger was released with improved performance to record time-locked event-related EEG signals. In this study, we were able to show in mice that pharmacological intervention with the NMDA receptor antagonists Ketamine and MK-801 can impair a comprehensive selection of EEG/ERP readouts (ERP N1 amplitude, 40 Hz ASSR, basal and e...Continue Reading

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Citations

May 7, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daniel C JavittThilo Womelsdorf
Jun 27, 2020·Frontiers in Psychiatry·Sokichi HondaTakuma Mihara
Apr 17, 2020·Frontiers in Neural Circuits·Jordan M Ross, Jordan P Hamm
Sep 10, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Yingzhuo LiLing Qin
Apr 29, 2021·Scientific Reports·David D AguilarJames M McNally

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Software Mentioned

SAS
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Analyzer2
MED
TSE
BrainVision Analyzer2

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