A Comprehensive Approach to Disentangle the Effect of Cerebellar Damage on Physical Disability in Multiple Sclerosis

Frontiers in Neurology
Serena RuggieriPatrizia Pantano

Abstract

Cerebellar damage occurs frequently in multiple sclerosis (MS) patients, with a wide exhibition of symptoms particularly as impairments of balance and gait. Recent studies implementing new postprocessing magnetic resonance imaging (MRI) techniques showed how cerebellar subregional atrophy provides an explanation of disability in MS. The aim of this work was to evaluate the relationship between quantitative measures of physical disability, cerebellar subregional atrophy, and cerebellar peduncle disruption. Forty-nine MS patients and 32 healthy subjects as controls (HS) underwent a 3-Tesla MRI including 3D T1-weighted and diffusion tensor imaging. Patients underwent static posturography to calculate the body's center of pressure (COP) displacement, Expanded Disability Status Scale (EDSS), and 25-ft walking test (25-FWT). Cerebellar lobular volumes were automatically calculated using the Spatially Unbiased Infratentorial Toolbox. Tract-based spatial statistics (TBSS) in FSL was used to process diffusion tensor imaging (DTI) Fit-generated fractional anisotropy (FA) maps to assess structural connectivity of cerebellar peduncles. Stepwise multivariate linear regression analyses were used to explore relationships between variables. Ce...Continue Reading

References

Jun 4, 1999·Brain : a Journal of Neurology·G R CutterE Willoughby
May 25, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Susanne M Morton, Amy J Bastian
Nov 12, 2005·Annals of Neurology·Chris H PolmanJerry S Wolinsky
Aug 15, 2006·NeuroImage·Jörn Diedrichsen
Oct 28, 2008·Brain : a Journal of Neurology·R A DineenD P Auer
May 5, 2009·Neuroscience·D TimmannB Schoch
May 22, 2009·NeuroImage·Jörn DiedrichsenNarender Ramnani
Dec 8, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Massimiliano CalabresePaolo Gallo
Feb 16, 2010·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Catherine J Stoodley, Jeremy D Schmahmann
Apr 23, 2011·Multiple Sclerosis : Clinical and Laboratory Research·V M AndersonO Ciccarelli
Sep 2, 2011·Human Brain Mapping·Marco BattagliniNicola De Stefano
Mar 26, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Veronica PopescuUNKNOWN MAGNIMS Study Group
Jun 13, 2013·Multiple Sclerosis : Clinical and Laboratory Research·Luca ProsperiniPatrizia Pantano
May 3, 2014·PloS One·Alfredo DamascenoFernando Cendes
Jan 13, 2015·The Cerebellum·Katrin WeierTill Sprenger
Oct 21, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Alessandro D'AmbrosioMaria A Rocca
Aug 28, 2017·Journal of Neurology, Neurosurgery, and Psychiatry·Sirio CocozzaMatilde Inglese
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Jan 14, 2018·Annals of Neurology·Arman EshaghiUNKNOWN MAGNIMS study group
Feb 27, 2018·Neuroscience and Biobehavioral Reviews·Katrin ParmarUNKNOWN MAGNIMS study group
Jun 16, 2018·Handbook of Clinical Neurology·Christophe Habas, Mario Manto
Jul 30, 2018·Journal of Neurology·Sirio CocozzaMaria Petracca
Nov 5, 2019·Multiple Sclerosis : Clinical and Laboratory Research·Ilena C GeorgeDaniel Pelletier
Nov 7, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Mohamed Mounir El MendiliMatilde Inglese

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Citations

Oct 26, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Maria PetraccaMatilde Inglese

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Software Mentioned

FMRIB
Statistical Parametric Mapping ( SPM12 )
FSL
TBSS
DTI Fit
Jim
Statistical Package for Social Sciences
SUIT
SPM12

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