A comprehensive assessment of environmental exposures among 1000 North American patients with primary sclerosing cholangitis, with and without inflammatory bowel disease

Alimentary Pharmacology & Therapeutics
J E EatonK N Lazaridis

Abstract

The relationships between primary sclerosing cholangitis (PSC) and the environment are largely unknown. To validate associations reported in previous studies and to identify novel environmental exposures among PSC patients. We performed a multicenter, case-control analysis utilising self-administered questionnaires. Responses between cases (n = 1000) and controls (n = 663) were compared using multivariable logistic regression adjusted for age and gender. The model was further stratified based on inflammatory bowel disease (IBD) status (with IBD n = 741 without IBD n = 259). Smoking was associated with PSC only when IBD was present (OR, 0.5; 95% CI 0.4-0.7) but not among those PSC patients without IBD (OR, 0.9; 95% CI 0.7-1.2). Compared to controls, women with PSC (irrespective of the presence of IBD) were less likely to have received hormone replacement therapy (HRT; OR, 0.5; 95% CI 0.4-0.7) and were more likely to have recurrent urinary tract infections (OR, 1.6; 95% CI 1.2-2.3). PSC patients regardless of gender or IBD status were less likely to eat fish (OR, 0.4; 95% CI 0.3-0.6) and grilled/barbecued meat (OR, 0.8; 95% CI 0.7-0.9). In contrast, PSC patients with and without IBD were more likely to consume steak/burgers that ...Continue Reading

References

Jan 1, 1990·Journal of Clinical Epidemiology·G BlockC Clifford
Sep 1, 1986·American Journal of Epidemiology·G BlockL Gardner
Jun 15, 1994·American Journal of Epidemiology·G BlockS M Scoppa
May 1, 1996·Gastroenterology·K J van ErpecumA Algra
Jul 1, 1996·The Journal of Clinical Investigation·T Caulin-GlaserJ R Bender
Jul 29, 2004·Journal of the American Dietetic Association·Teresia GoldbergHelen Vlassara
Nov 24, 2006·Mayo Clinic Proceedings·Suhal S MahidSusan Galandiuk
Jul 31, 2007·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·B-O Nilsson
Jan 8, 2008·The American Journal of Gastroenterology·Sunanda V Kane, Deepa Reddy
Dec 18, 2008·The American Journal of Gastroenterology·Kelvin T ThiaSuk-Kyun Yang
Sep 5, 2009·Epidemiology·Magdalena RosellUNKNOWN EIRA study group
Jan 27, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Roger ChapmanUNKNOWN American Association for the Study of Liver Diseases
May 26, 2010·Journal of the American Dietetic Association·Jaime UribarriHelen Vlassara
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claire Barbier de La SerreHelen E Raybould
Apr 19, 2011·The Journal of Nutritional Biochemistry·Wen-Ying ChenChun-Jung Chen
Nov 26, 2011·Journal of Crohn's & Colitis·M Barreiro-de AcostaJ E Dominguez-Muñoz
Nov 24, 2012·Journal of Gastroenterology and Hepatology·Michelle GoodwinPeter Angus
Jan 22, 2013·Gut·Siew C NgUNKNOWN Epidemiology and Natural History Task Force of the International Organization of Inflammatory Bowel Disease (IOIBD)
Mar 16, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Craig LammertKonstantinos N Lazaridis
May 15, 2013·The Proceedings of the Nutrition Society·Philip C Calder
Jun 19, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirsten BoonstraUNKNOWN EpiPSCPBC Study Group
Oct 1, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Ina Marie AndersenJohannes Roksund Hov
Nov 16, 2013·BioMed Research International·James H TabibianKeith D Lindor
Dec 18, 2013·Current Allergy and Asthma Reports·Arndt ManzelMarkus Kleinewietfeld
Jan 1, 2014·Alimentary Pharmacology & Therapeutics·T H KarlsenK M Boberg
Jan 7, 2014·Annual Review of Food Science and Technology·Anne Salonen, Willem M de Vos
Jan 21, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Craig LammertKonstantinos N Lazaridis
Feb 25, 2014·Gastroenterology·Aleksandar D KosticDirk Gevers
Oct 4, 2014·Current Vascular Pharmacology·Carlos ScherrAndrei C Sposito

❮ Previous
Next ❯

Citations

Feb 10, 2016·Alimentary Pharmacology & Therapeutics·J TorresJ Hu
Jun 17, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Kirsten BoonstraUNKNOWN Epi PSC PBC Study Group
Nov 26, 2015·Clinics in Liver Disease·Souvik Sarkar, Christopher L Bowlus
May 6, 2015·Alimentary Pharmacology & Therapeutics·D N Assis, C Levy
Sep 23, 2016·The New England Journal of Medicine·Konstantinos N Lazaridis, Nicholas F LaRusso
Jun 19, 2019·Clinical and Translational Gastroenterology·Craig LammertElizabeth J Phillips
Nov 9, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Angela C CheungKonstantinos N Lazaridis
May 26, 2020·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Dong-Won Ahn
Jul 7, 2018·Health and Quality of Life Outcomes·Fatima IsaMelanie Calvert
Jun 9, 2018·United European Gastroenterology Journal·Karn WijarnpreechaPatompong Ungprasert
May 14, 2018·AIMS Microbiology·Kerri GlassnerDavid W Victor
Jan 22, 2021·JHEP Reports : Innovation in Hepatology·Jessica Katharine DysonDavid Emrys Jeffreys Jones
Jun 6, 2020·Endocrinología, Diabetes Y Nutrición·Mariangela RondanelliAlessandra Miccono
Mar 22, 2021·Health and Quality of Life Outcomes·Elena MarcusBella Vivat
May 4, 2021·Digestive Diseases and Sciences·Craig LammertKonstantinos N Lazaridis
May 13, 2021·Liver International : Official Journal of the International Association for the Study of the Liver·Craig LammertKonstantinos N Lazaridis
Jul 17, 2021·Gut·Palak J Trivedi, Gideon M Hirschfield
Aug 18, 2021·Clinics and Research in Hepatology and Gastroenterology·Sander JuliaRupp Christian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Australian and New Zealand Journal of Medicine
J C OngK J Gaskin
European Journal of Gastroenterology & Hepatology
Wim van de VrieHerold J Metselaar
The Turkish Journal of Gastroenterology : the Official Journal of Turkish Society of Gastroenterology
Necla OsmanoğluOktay Tekeşin
© 2021 Meta ULC. All rights reserved