A Comprehensive Assessment of the Value of Laboratory Indices in Diagnosing Kawasaki Disease

Arthritis & Rheumatology
Qing YeChun-chun Zhang

Abstract

Kawasaki disease (KD) is the primary cause of heart disease among children, but because its clinical symptoms are nonspecific, it is difficult to diagnose. The purpose of this study was to evaluate laboratory indices for possible use in the early diagnosis of KD and to determine which indices are predictive of a response to intravenous immunoglobulin (IVIG) and can be used to monitor the effects of treatment. Three hundred thirty KD patients, 330 age-matched children with KD-like febrile disease, and 330 age-matched healthy children (controls) were enrolled in this prospective study. Levels of N-terminal pro-brain natriuretic peptide (NT-proBNP), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and cytokines were determined in all study subjects. In the derivation cohort, 181 patients in the KD group were compared with 181 patients in the KD-like febrile group. The following indices were found to be useful in the diagnosis of KD: NT-proBNP (area under the curve [AUC] 0.923), ESR (AUC 0.909), CRP (AUC 0.834), and interleukin-6 (IL-6; AUC 0.678). The diagnostic efficiency of each index demonstrated in the derivation cohort was repeated in the 149 KD patients in the validation cohort. There were significant differen...Continue Reading

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Citations

Feb 18, 2016·Rheumatology International·Durga Prasanna Misra, Sajjan N Shenoy
Sep 25, 2015·Indian Journal of Pediatrics·Surjit SinghFuyong Jiao
Aug 16, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Qing YeJian Hu
Sep 4, 2016·Expert Review of Clinical Immunology·Shreya Agarwal, Devendra K Agrawal
Sep 3, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Audrey DionneNagib Dahdah
Mar 23, 2019·Biomarkers in Medicine·Moises Rodriguez-GonzalezHelena M Cascales-Poyatos
Jul 24, 2020·The Journal of Clinical Investigation·Pui Y LeeMary Beth F Son

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