A Comprehensive Biological and Clinical Perspective Can Drive a Patient-Tailored Approach to Multiple Myeloma: Bridging the Gaps between the Plasma Cell and the Neoplastic Niche

Journal of Oncology
Antonio Giovanni SolimandoDomenico Ribatti

Abstract

There is a broad spectrum of diseases labeled as multiple myeloma (MM). This is due not only to the composite prognostic risk factors leading to different clinical outcomes and responses to treatments but also to the composite tumor microenvironment that is involved in a vicious cycle with the MM plasma cells. New therapeutic strategies have improved MM patients' chances of survival. Nevertheless, certain patients' subgroups have a particularly unfavorable prognosis. Biological stratification can be subdivided into patient, disease, or therapy-related factors. Alternatively, the biological signature of aggressive disease and dismal therapeutic response can promote a dynamic, comprehensive strategic approach, better tailoring the clinical management of high-risk profiles and refractoriness to therapy and taking into account the role played by the MM milieu. By means of an extensive literature search, we have reviewed the state-of-the-art pathophysiological insights obtained from translational investigations of the MM-bone marrow microenvironment. A good knowledge of the MM niche pathophysiological dissection is crucial to tailor personalized approaches in a bench-bedside fashion. The discussion in this review pinpoints two main ...Continue Reading

References

Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·R J D'AmatoJ Folkman
Jul 1, 1994·British Journal of Haematology·A VaccaF Dammacco
May 19, 2000·Cell Biology International·K GadóA Falus
Oct 18, 2001·Radiation Research·F Pajonk, W H McBride
Dec 12, 2001·Seminars in Oncology·S V Rajkumar, R A Kyle
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S Vincent RajkumarThomas E Witzig
Feb 14, 2003·Seminars in Oncology·Philippe Clézardin
Jul 12, 2003·Blood·Angelo VaccaFranco Dammacco
Nov 3, 2004·The Journal of Clinical Investigation·Takayuki NakayamaGiovanna Tosato
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Michael G AlexandrakisEfstathios Stathopoulos
Apr 6, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip R GreippJan Westin
Apr 15, 2005·Nature·Tannishtha Reya, Hans Clevers
Jun 9, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Angelo VaccaPaolo Corradini
Aug 22, 2006·Blood Reviews·Zhi-Wei Li, William S Dalton
Nov 16, 2006·Clinical Rheumatology·D RibattiF P Cantatore
Dec 16, 2006·Current Pharmaceutical Biotechnology·A M RoccaroK C Anderson
Nov 17, 2007·Cancer Research·Yulia NefedovaDmitry I Gabrilovich
Dec 20, 2007·Molecular Cancer Therapeutics·Claudio ScavelliAngelo Vacca
Jan 22, 2008·Stem Cells and Development·Beatrice NicoDomenico Ribatti
Jan 26, 2008·The Journal of Clinical Investigation·Siddhartha MukherjeeDavid T Scadden
Jun 19, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ana O HoffGabriel N Hortobagyi
Feb 7, 2009·Nature Reviews. Immunology·Dmitry I Gabrilovich, Srinivas Nagaraj
Aug 20, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto RiaAngelo Vacca
Feb 9, 2011·Leukemia & Lymphoma·Giovanni D'ArenaUNKNOWN Gisl (Gruppo Italiano Studio Linfomi) Cooperative Group
Jun 28, 2011·Advances in Cancer Research·Miguel LemaireKarin Vanderkerken
Jul 21, 2011·The Lancet Oncology·Gareth J MorganUNKNOWN National Cancer Research Institute Haematological Oncology Clinical Studies Group
Feb 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pasquale Sansone, Jacqueline Bromberg
Mar 17, 2012·British Journal of Haematology·Sabino CiavarellaFranco Silvestris

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Citations

Jul 16, 2020·Cancers·Antonio Giovanni SolimandoDomenico Ribatti
Apr 4, 2021·International Journal of Molecular Sciences·Dominika BębnowskaPaulina Niedźwiedzka-Rystwej

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Methods Mentioned

BETA
X-ray
ISS
biopsies
electron microscopy
enzyme-linked immunosorbent assay
SMA

Clinical Trials Mentioned

NCT02289222
NCT02331368

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