A comprehensive catalogue of the coding and non-coding transcripts of the human inner ear.

Hearing Research
Isabelle SchrauwenRick A Friedman

Abstract

The mammalian inner ear consists of the cochlea and the vestibular labyrinth (utricle, saccule, and semicircular canals), which participate in both hearing and balance. Proper development and life-long function of these structures involves a highly complex coordinated system of spatial and temporal gene expression. The characterization of the inner ear transcriptome is likely important for the functional study of auditory and vestibular components, yet, primarily due to tissue unavailability, detailed expression catalogues of the human inner ear remain largely incomplete. We report here, for the first time, comprehensive transcriptome characterization of the adult human cochlea, ampulla, saccule and utricle of the vestibule obtained from patients without hearing abnormalities. Using RNA-Seq, we measured the expression of >50,000 predicted genes corresponding to approximately 200,000 transcripts, in the adult inner ear and compared it to 32 other human tissues. First, we identified genes preferentially expressed in the inner ear, and unique either to the vestibule or cochlea. Next, we examined expression levels of specific groups of potentially interesting RNAs, such as genes implicated in hearing loss, long non-coding RNAs, pse...Continue Reading

References

Nov 4, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·M C SimmlerJ J Panthier
Aug 17, 2001·Hearing Research·A El-AmraouiM C Simmler
Jan 5, 2002·The Journal of Investigative Dermatology. Symposium Proceedings·S ShibaharaK Takahashi
Jun 27, 2002·Journal of the Association for Research in Otolaryngology : JARO·Barbara L ResendesCynthia C Morton
Mar 12, 2004·Genes & Development·Rainer PaffenholzDavid E Bergstrom
Dec 13, 2005·Journal of Neuroscience Research·Shehnaaz S M ManjiHans-Henrik M Dahl
Aug 19, 2010·Journal of Biomedical Science·Shahrooz VahediKambiz N Alavian
Feb 18, 2011·Genome Biology·Li YangLing-Ling Chen
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Jun 20, 2012·Hearing Research·Ronna Hertzano, Ran Elkon
Jun 23, 2012·Genome Research·Simon AndersWolfgang Huber
Jun 26, 2012·Cell·Shanker Kalyana-SundaramArul M Chinnaiyan
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Oct 30, 2012·Bioinformatics·Alexander DobinThomas R Gingeras
Feb 14, 2013·PloS One·Caroline FlegelGünter Gisselmann
Apr 17, 2013·Cellular and Molecular Life Sciences : CMLS·Ivan ContePaola Bovolenta
Sep 17, 2013·Nature·Tuuli LappalainenEmmanouil T Dermitzakis
Jan 7, 2014·Frontiers in Molecular Neuroscience·Kathy UshakovKaren B Avraham
Mar 29, 2014·PloS One·Hidekane YoshimuraShin-ichi Usami
Jun 15, 2014·BMC Genomics·Yehudit Hasin-BrumshteinThomas A Drake
Apr 24, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Déborah I SchefferZheng-Yi Chen

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Citations

Aug 4, 2016·American Journal of Human Genetics·Frauke CoppietersElfride De Baere
Sep 3, 2016·American Journal of Human Genetics·Konstantinos NikopoulosCarlo Rivolta
Jan 13, 2018·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Amal BouzidSaber Masmoudi
Feb 28, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Mohammad Amin TabatabaiefarJavad Mohammadi-Asl
Oct 28, 2019·Scientific Reports·Andries Paul NagtegaalAndré Goedegebure
Jan 28, 2020·Ear and Hearing·Elina KariIsabelle Schrauwen
May 7, 2020·Ophthalmic Genetics·Rosalie M NolenWadih M Zein
Aug 23, 2018·Frontiers in Aging Neuroscience·Amal BouzidSaber Masmoudi
Jul 8, 2020·Journal of Medical Genetics·Suzanne E de BruijnUNKNOWN DOOFNL Consortium
Apr 28, 2020·Human Molecular Genetics·Karina LezirovitzJeanne Oiticica
May 6, 2020·Scientific Reports·Alyona KederJoerg T Albert
Mar 16, 2019·European Journal of Human Genetics : EJHG·Isabelle SchrauwenSuzanne M Leal
Jul 1, 2020·Laryngoscope Investigative Otolaryngology·Madeline P Pyle, Michael Hoa
Dec 5, 2019·The Journal of the Acoustical Society of America·Jane A BurtonRamnarayan Ramachandran
Apr 7, 2020·Ear and Hearing·Pablo Roman-NaranjoJose Antonio Lopez-Escamez
Nov 3, 2020·Ear and Hearing·Pablo Roman-NaranjoJose Antonio Lopez-Escamez
Nov 3, 2020·RNA Biology·Tal Koffler-BrillKaren B Avraham
Dec 3, 2020·Genes·Alba Escalera-BalseraJose Antonio Lopez-Escamez
May 11, 2021·Frontiers in Cell and Developmental Biology·Giulia AscariElfride De Baere
May 18, 2021·Human Molecular Genetics·Ichiro FukunagaKazusaku Kamiya
Aug 24, 2021·Frontiers in Cellular Neuroscience·Janani S IyerKonstantina M Stankovic
Sep 13, 2021·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Lacey NelsonMichael Hoa

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