A comprehensive evaluation of IL4 variants in ethnically diverse populations: association of total serum IgE levels and asthma in white subjects

The Journal of Allergy and Clinical Immunology
Monica J BasehoreEugene R Bleecker

Abstract

The role of variation in the IL4 gene in asthma and allergy susceptibility is controversial. This cytokine is important in IgE isotype switching and the regulation of allergic inflammation; however, published studies have not delineated the specific role of variation in this gene in allergic disorders. We sought to identify single nucleotide polymorphisms (SNPs) in IL4 and to evaluate the association of SNPs and haplotypes with asthma and allergic phenotypes (total serum IgE) in white, African American, and Hispanic asthmatic populations. Sixteen individuals were resequenced, and 19 SNPs were identified; 2 novel and 17 SNPs were previously reported. Eleven of the SNPs were used to evaluate association in the 3 groups. Nine polymorphisms were associated with total serum IgE levels in white subjects (.0012 < or = P < or =.034), and 5 of these were also associated with asthma in this population (.010 < or = P < or =.031). Three common haplotypes were observed, and all were associated with either high or low serum IgE levels in white subjects (.00008 < or = P < or =.004). Inspection of the haplotypes revealed that 3017 G/T in intron 2 was the only SNP concordant with serum IgE levels (G allele with lower levels and T allele with hi...Continue Reading

References

Oct 1, 1975·The Journal of Allergy and Clinical Immunology·H ChaiR G Townley
Jan 1, 1990·The American Review of Respiratory Disease·R J HoppN M Nair
Feb 2, 1989·The New England Journal of Medicine·B BurrowsM G Cline
Dec 24, 1981·The New England Journal of Medicine·D G MarshW B Bias
Oct 5, 1995·The New England Journal of Medicine·D S PostmaR C Levitt
Nov 1, 1995·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·L J RosenwasserL Borish
Apr 1, 1996·American Journal of Respiratory and Critical Care Medicine·I J DoullN E Morton
Aug 1, 1996·Journal of Medical Genetics·A J Walley, W O Cookson
Dec 11, 1997·The New England Journal of Medicine·G K HersheyT A Chatila
Jun 26, 1998·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·E NoguchiH Hamaguchi
Jul 28, 1999·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·T D HowardE R Bleecker
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·E G BurchardJ M Drazen
Nov 7, 1999·The Journal of Allergy and Clinical Immunology·D G WieschE R Bleecker
Mar 4, 2000·Human Molecular Genetics·A HeinzmannK A Deichmann
Jul 25, 2000·Clinics in Chest Medicine·C Ober, M F Moffatt
Oct 12, 2000·American Journal of Human Genetics·J XuD A Meyers
Nov 23, 2000·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G ChinettiB Staels
Dec 21, 2000·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·I SuzukiY Kawakami
Feb 24, 2001·Genes and Immunity·T C van der Pouw KraanJ S van der Zee
Sep 7, 2001·The Journal of Allergy and Clinical Immunology·L A LesterUNKNOWN Collaborative Study on the Genetics of Asthma
Oct 6, 2001·American Journal of Respiratory Cell and Molecular Biology·T D HowardE R Bleecker
Dec 13, 2001·American Journal of Human Genetics·Timothy D HowardEugene R Bleecker
Jan 16, 2002·American Journal of Human Genetics·Daniel J SchaidGregory A Poland
Jul 12, 2002·Nature·Paul Van EerdeweghTim P Keith
Feb 20, 2003·The Journal of Allergy and Clinical Immunology·John W SteinkeLanny J Rosenwasser
Apr 22, 2003·The Journal of Allergy and Clinical Immunology·Susan ColillaUNKNOWN Collaborative Study for the Genetics of Asthma
Oct 21, 2003·Nature Genetics·Maxine AllenWilliam O C M Cookson
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Michael KabeschFernando D Martinez

❮ Previous
Next ❯

Citations

Apr 11, 2008·Human Genetics·Shweta ChoudhryEsteban González Burchard
Jul 27, 2007·Cancer Causes & Control : CCC·Mark P PurdueSophia S Wang
May 4, 2011·Clinical Reviews in Allergy & Immunology·Albin B LeongJuan C Celedón
Feb 28, 2008·Nature Reviews. Immunology·Donata Vercelli
Sep 12, 2007·Annual Review of Medicine·Stefano Guerra, Fernando D Martinez
May 31, 2007·International Archives of Allergy and Immunology·Judith C W MakMoira Chan-Yeung
Oct 8, 2005·American Journal of Respiratory and Critical Care Medicine·Gary M HunninghakeJuan C Celedón
Aug 26, 2006·American Journal of Respiratory and Critical Care Medicine·Gregory A HawkinsEugene R Bleecker
Dec 16, 2006·American Journal of Respiratory and Critical Care Medicine·Sally E WenzelEugene R Bleecker
Feb 17, 2007·American Journal of Respiratory and Critical Care Medicine·Natalie C BattleUNKNOWN SAGE Investigators
Sep 5, 2009·American Journal of Respiratory and Critical Care Medicine·Gerard H KoppelmanDirkje S Postma
Apr 13, 2010·American Journal of Respiratory and Critical Care Medicine·Larry Borish
Nov 30, 2005·Clinical and Molecular Allergy : CMA·María Isidoro-GarcíaRogelio González-Sarmiento
Jun 19, 2014·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Zhi-Peng LiLi-Si Liu
Sep 25, 2015·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Jingyun LiLuo Zhang
Oct 1, 2013·American Journal of Otolaryngology·Masoud MovahediNima Rezaei
Dec 6, 2007·Chest·Christina V Scirica, Juan C Celedón
Nov 6, 2010·The Journal of Allergy and Clinical Immunology·Xiumei HongXiaobin Wang
Nov 17, 2009·The Journal of Allergy and Clinical Immunology·Gabe HallerEmma E Thompson
Nov 23, 2007·Cancer Detection and Prevention·Sara H OlsonRobert C Kurtz
Nov 1, 2005·Immunology and Allergy Clinics of North America·Alicia K Smith, Deborah A Meyers
Nov 1, 2005·Immunology and Allergy Clinics of North America·Michael Kabesch
Aug 2, 2006·Clinics in Chest Medicine·Robyn T Cohen, Juan C Celedón
Dec 23, 2015·Journal of Immunology Research·Léa Campos de OliveiraGilda Porta
Oct 15, 2013·Biological Reviews of the Cambridge Philosophical Society·Elena S GusarevaMarie Lipoldová
Feb 13, 2007·The Journal of Allergy and Clinical Immunology·Gareth BaynamPeter LeSouef
Sep 4, 2015·International Forum of Allergy & Rhinology·Elina Toskala, David W Kennedy
Jun 15, 2016·The Journal of Allergy and Clinical Immunology·Jayanta GuptaTesfaye B Mersha
Jul 2, 2005·The Journal of Allergy and Clinical Immunology·Donata Vercelli
Mar 1, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas KleinrathReinhold Ramoner
Oct 22, 2014·Journal of Child Neurology·Ameneh Zare-ShahabadiNima Rezaei
Jan 25, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcus J RobinsonGraham Le Gros

❮ Previous
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