A Comprehensive Evaluation of Mepolizumab Effectiveness in a Real-Life Setting.

International Archives of Allergy and Immunology
Paolo CameliElena Bargagli

Abstract

Interleukin-5 (IL-5) is the principal cytokine regulating eosinophil growth, differentiation, activation, and expression. It is a specific target of mepolizumab, an anti-IL-5 monoclonal antibody used in the treatment of severe eosinophilic asthma. This new drug can improve symptoms, reduce asthma exacerbations and steroid use. Few data are available on its efficacy for nasal symptoms. To describe the all-round clinical impact of mepolizumab in a real-life setting, evaluating the efficacy and safety of the drug in severe eosinophilic asthma patients. We retrospectively collected the clinical and functional data on 27 patients (16 males) affected with severe eosinophilic asthma, diagnosed at the Siena Regional Referral Centre and monitored for 6 months. Clinical, immunological, and functional data at baseline and follow-up were entered in a database together with comorbidities, number of exacerbations, steroid treatment, multiple-flow exhaled nitric oxide, and validated questionnaires. A significant reduction in asthma exacerbations was observed in all patients after 6 months of the biological therapy (p = 0.0009), and 4/6 patients discontinued chronic oral steroids. A significant improvement in ACT, FEV1, SNOT22, and alveolar ni...Continue Reading

References

Jul 9, 2017·The Journal of Allergy and Clinical Immunology·Claus BachertWytske J Fokkens
Sep 4, 2019·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Barak PertzovMordechai Reuven Kramer
Jan 31, 2020·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jermo Johannes van ToorGert Jan Braunstahl

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Citations

Feb 20, 2021·Scandinavian Journal of Immunology·Laura BergantiniElena Bargagli
Apr 10, 2021·Journal of Asthma and Allergy·Hyo-In RhyouYoung-Hee Nam
Aug 4, 2021·Molecular Diagnosis & Therapy·Laura BergantiniElena Bargagli
Dec 25, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Elliot IsraelRafael Alfonso-Cristancho

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