A comprehensive evaluation of the toxicology of experimental, non-filtered cigarettes manufactured with different circumferences

Inhalation Toxicology
Christopher R E CogginsMichael J Oldham

Abstract

Historical work indicates that cigarette circumference may affect the toxicological profile of experimental cigarettes. Studies were conducted to examine the effect of different cigarette circumferences on (1) selected mainstream smoke constituents including concentrations of tobacco specific nitrosamines (TSNA) in smoke and (2) mutagenicity and cytotoxicity of cigarette smoke condensate. Analytical chemistry, Salmonella mutagenicity and cytotoxicity assays were used to evaluate the composition and biological activity of mainstream smoke from experimental, non-filtered cigarettes manufactured with four different circumferences (17.0-27.1 mm). Most smoke constituents, including TSNA, decreased with decreasing cigarette circumference; however, amounts of hydrogen cyanide increased in a non-circumference dependent manner. Mutagenicity and cytotoxicity also decreased slightly with decreasing cigarette circumference. Cigarette circumference may have a minor role in the toxicological profile of experimental cigarettes, with a so-far-unidentified mechanism.

References

May 1, 1992·Human & Experimental Toxicology·K Ungar
Dec 4, 2001·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·E RoemerE L Carmines
Oct 25, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·K P PutnamD J Doolittle

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Citations

Dec 6, 2014·Behavioural Neurology·Philip Adeyemi AdeniyiOlalekan Michael Ogundele
Mar 1, 2016·Environmental and Molecular Mutagenesis·Sung Gu HanC Gary Gairola
Aug 26, 2014·Regulatory Toxicology and Pharmacology : RTP·Madeleine AshleyKrishna Prasad
Sep 17, 2016·Regulatory Toxicology and Pharmacology : RTP·Kevin McAdamAndrew Porter

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