A comprehensive fluid-structure interaction model of the left coronary artery

Journal of Biomechanical Engineering
Daphne MezaWei Yin

Abstract

A fluid structure interaction model of a left anterior descending (LAD) coronary artery was developed, incorporating transient blood flow, cyclic bending motion of the artery, and myocardial contraction. The 3D geometry was constructed based on a patient's computed tomography angiography data. To simulate disease conditions, a plaque was placed within the LAD to create a 70% stenosis. The bending motion of the blood vessel was prescribed based on the LAD spatial information. The pressure induced by myocardial contraction was applied to the outside of the blood vessel wall. The fluid domain was solved using the Navier-Stokes equations. The arterial wall was defined as a nonlinear elastic, anisotropic, and incompressible material, and the mechanical behavior was described using the modified hyper-elastic Mooney-Rivlin model. The fluid (blood) and solid (vascular wall) domains were fully coupled. The simulation results demonstrated that besides vessel bending/stretching motion, myocardial contraction had a significant effect on local hemodynamics and vascular all stress/strain distribution. It not only transiently increased blood flow velocity and fluid wall shear stress, but also changed shear stress patterns. The presence of the...Continue Reading

References

Dec 11, 1999·JAMA : the Journal of the American Medical Association·A M MalekS Izumo
May 3, 2000·Journal of Biomechanical Engineering·Y Qiu, J M Tarbell
May 2, 2003·Annals of Biomedical Engineering·Dehong ZengC Ross Ethier
Sep 25, 2004·Journal of Biomechanics·Martin ProsiMorton H Friedman
Sep 28, 2004·Annals of Biomedical Engineering·Wei YinDanny Bluestein
Oct 9, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Anil K JoshiC Ross Ethier
Nov 30, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Kristopher S Cunningham, Avrum I Gotlieb
Mar 31, 2005·Journal of Biomechanical Engineering·Wei ZhangGhassan S Kassab
Jul 5, 2005·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Rafael Florenciano-SánchezMariano Valdés-Chávarri
Mar 30, 2006·Journal of Magnetic Resonance Imaging : JMRI·Sandra R R TecelãoJ Tim Marcus
Dec 11, 2007·European Heart Journal·Serge A van WolferenAnton Vonk-Noordegraaf
Apr 30, 2009·Annual Review of Biomedical Engineering·C A Taylor, C A Figueroa
Jun 2, 2009·American Journal of Physiology. Heart and Circulatory Physiology·Jenny Susana Choy, Ghassan S Kassab
Feb 9, 2010·Computer Methods in Biomechanics and Biomedical Engineering·I E Vignon-ClementelC A Taylor
Apr 20, 2010·Expert Review of Cardiovascular Therapy·Saurabh S DhawanHabib Samady
Oct 5, 2010·Journal of Biomechanical Engineering·Saravan Kumar ShanmugavelayudamWei Yin
Jun 21, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Jacques OhayonRoderic I Pettigrew
Jun 1, 2013·Journal of Biomechanical Engineering·Samarth S RautEnder A Finol
Sep 7, 2013·Journal of Biomechanical Engineering·Mahmudul HasanWei Yin
Jun 7, 2014·Circulation Research·Jacob Fog BentzonErling Falk
Jun 10, 2016·Cardiovascular Diagnosis and Therapy·Arun MahalingamJasjit S Suri
Jul 29, 2016·Computer Methods in Biomechanics and Biomedical Engineering·Ashkan JavadzadeganLeonard Kritharides

❮ Previous
Next ❯

Citations

May 11, 2019·Journal of Biomechanical Engineering·Parastou EslamiAlison Marsden
May 28, 2019·The International Journal of Cardiovascular Imaging·Áron ÜvegesZsolt Kőszegi
Feb 23, 2020·Medical Engineering & Physics·Matthew HirschhornAmy Throckmorton
Apr 1, 2021·Computer Methods and Programs in Biomedicine·Sreelakshmi Sandeep, S R Shine
Mar 23, 2021·International Journal for Numerical Methods in Biomedical Engineering·Longzhu HanXiao Liu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.