PMID: 9423856Jan 10, 1998Paper

A comprehensive genetic study of streptococcal immunoglobulin A1 proteases: evidence for recombination within and between species

Infection and Immunity
Knud PoulsenM Kilian

Abstract

An analysis of 13 immunoglobulin A1 (IgA1) protease genes (iga) of strains of Streptococcus pneumoniae, Streptococcus oralis, Streptococcus mitis, and Streptococcus sanguis was carried out to obtain information on the structure, polymorphism, and phylogeny of this specific protease, which enables bacteria to evade functions of the predominant Ig isotype on mucosal surfaces. The analysis included cloning and sequencing of iga genes from S. oralis and S. mitis biovar 1, sequencing of an additional seven iga genes from S. sanguis biovars 1 through 4, and restriction fragment length polymorphism (RFLP) analyses of iga genes of another 10 strains of S. mitis biovar 1 and 6 strains of S. oralis. All 13 genes sequenced had the potential of encoding proteins with molecular masses of approximately 200 kDa containing the sequence motif HEMTH and an E residue 20 amino acids downstream, which are characteristic of Zn metalloproteinases. In addition, all had a typical gram-positive cell wall anchor motif, LPNTG, which, in contrast to such motifs in other known streptococcal and staphylococcal proteins, was located in their N-terminal parts. Repeat structures showing variation in number and sequence were present in all strains and may be of ...Continue Reading

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Citations

Sep 13, 2001·Infection and Immunity·J HohwyM Kilian
Jan 30, 2002·The Journal of Biological Chemistry·Klaudia KosowskaKnud Poulsen
Jun 10, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bernard W Senior, Jenny M Woof
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