A comprehensive guide to telocytes and their great potential in cardiovascular system

Bratislavské lekárske listy
I KucybalaM K Holda

Abstract

Telocytes, a recently discovered type of interstitial cells, have a very distinctive morphology - the small cell body with long extensions, named telopodes. In our review, apart from introducing general aspects of telocytes, we focus on properties, functions and future potential of those cells in cardiovascular system. However, physiological functions of telocytes in cardiovascular system are still regarded as quite enigmatic. Previous studies claim that they play a role in organogenesis and regeneration, bioelectrical signalling, mechanoelectrical coupling, anti-oxidative protection, angiogenesis and regulation of blood flow. As well, they are presumably connected with the presence of blood-myocardium barrier and proper organisation of extracellular matrix. Moreover, there exists a significant link between the quantity of telocytes in tissue and numerous cardiovascular diseases such as: myocardial infarction, cardiomyopathies, systemic sclerosis, heart failure, atrial fibrillation, isolated atrial amyloidosis, myxomatous valve degeneration and hyperplastic consequences of vascular injury. Thanks to their unique properties, telocytes might be a breakthrough in treatment of cardiovascular diseases, as they may be effective in re...Continue Reading

Citations

Jul 6, 2020·Journal of Cardiovascular Electrophysiology·Elżbieta SzczepanekMateusz K Hołda
Mar 13, 2021·Scientific Reports·Soha A Soliman
Apr 30, 2021·Frontiers in Physiology·Maria Cimini, Raj Kishore

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