Jan 1, 1989

A comprehensive laboratory evaluation of changes in the fibrinogen molecule in the diagnosis of acquired coagulopathy conditions

Laboratornoe delo
V A SiatkovskiĭP L Vasilenko

Abstract

A scheme of physicochemical determination of fibrinogen and the major molecular derivatives in a single sample of plasma is suggested, available for the majority of clinical laboratories. Such determination gives valuable information for a clinician. Among other things, the level of rapidly thrombin clotted fibrinogen portion is determined, as is the content of high-molecular fibrin monomer complexes, not clotted with thrombin, and the level of fibrinogen and fibrin proteolytic degradation products. Clinical (in 42 patients with various conditions) and experimental (coagulopathy in amniotic fluid embolism) application of this scheme has confirmed its clinico-diagnostic value.

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Mentioned in this Paper

Fibrin Measurement
Amniotic Fluid Pulmonary Embolism
Disseminated Intravascular Coagulation
Derivatives
Fibrinogen
Fibrinogen Assay
F2 gene
Thrombin
Proteolytic Enzyme
Blood Coagulation Disorders

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