A Comprehensive Method To Quantify Adaptations by Male and Female Mice With Hot Flashes Induced by the Neurokinin B Receptor Agonist Senktide

Endocrinology
Ashley A KrullRobert A Steiner

Abstract

Vasomotor symptoms (VMS; or hot flashes) plague millions of reproductive-aged men and women who have natural or iatrogenic loss of sex steroid production. Many affected individuals are left without treatment options because of contraindications to hormone replacement therapy and the lack of equally effective nonhormonal alternatives. Moreover, development of safer, more effective therapies has been stymied by the lack of an animal model that recapitulates the hot-flash phenomenon and enables direct testing of hypotheses regarding the pathophysiology underlying hot flashes. To address these problems, we developed a murine model for hot flashes and a comprehensive method for measuring autonomic and behavioral thermoregulation in mice. We designed and constructed an instrument called a thermocline that produces a thermal gradient along which mice behaviorally adapt to a thermal challenge to their core body temperature set point while their thermal preference over time is tracked and recorded. We tested and validated this murine model for VMS by administration of a TRPV1 agonist and a neurokinin B receptor agonist, capsaicin and senktide, respectively, to unrestrained mice and observed their autonomic and behavioral responses. Foll...Continue Reading

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Citations

Mar 29, 2020·Menopause : the Journal of the North American Menopause Society·Sally A D RomeroJun J Mao
Oct 12, 2018·Endocrine·Maria Alice OliveiraValéria Ernestânia Chaves
Apr 25, 2018·Temperature : Multidisciplinary Biomedical Journal·Sally J Krajewski-HallNaomi E Rance
Apr 16, 2021·Endocrinology·Shannon B Z Stephens, Alexander S Kauffman
Aug 14, 2021·The Journal of Clinical Endocrinology and Metabolism·Elizabeth A McCarthyVictor M Navarro

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