A comprehensive overview of the medicinal chemistry of antifungal drugs: perspectives and promise

Chemical Society Reviews
Kaitlind C HowardSylvie Garneau-Tsodikova

Abstract

The emergence of new fungal pathogens makes the development of new antifungal drugs a medical imperative that in recent years motivates the talents of numerous investigators across the world. Understanding not only the structural families of these drugs but also their biological targets provides a rational means for evaluating the merits and selectivity of new agents for fungal pathogens and normal cells. An equally important aspect of modern antifungal drug development takes a balanced look at the problems of drug potency and drug resistance. The future development of new antifungal agents will rest with those who employ synthetic and semisynthetic methodology as well as natural product isolation to tackle these problems and with those who possess a clear understanding of fungal cell architecture and drug resistance mechanisms. This review endeavors to provide an introduction to a growing and increasingly important literature, including coverage of the new developments in medicinal chemistry since 2015, and also endeavors to spark the curiosity of investigators who might enter this fascinatingly complex fungal landscape.

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Citations

Jul 17, 2020·Expert Review of Anti-infective Therapy·Mubashshir RasheedRupinder Kaur
Mar 1, 2021·European Journal of Medicinal Chemistry·Seong-Heun KimDaniele Castagnolo
Oct 15, 2020·International Journal of Molecular Sciences·Clément DezanetJean-Luc Décout
Mar 9, 2021·Computational and Structural Biotechnology Journal·Raghav VijSascha Brunke
Apr 22, 2021·BioMed Research International·Danielle da Nóbrega AlvesRicardo Dias de Castro
May 29, 2021·The Journal of Organic Chemistry·Maneesh Kumar Reddy SingamMaddi Sridhar Reddy
Jun 1, 2021·ACS Omega·Srilok SrinivasanSubramanian K R S Sankaranarayanan
Jul 28, 2021·Chemical Society Reviews·Yan LinGilles Gasser
Oct 17, 2020·ChemMedChem·Nishad Thamban ChandrikaSylvie Garneau-Tsodikova
Jul 22, 2020·Journal of Medicinal Chemistry·Wei LiuShengzheng Wang

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Methods Mentioned

BETA
deamination
acylation

Clinical Trials Mentioned

NCT03734991
NCT03583164
NCT03604707
NCT02022215
NCT03327727
NCT00978523
NCT00509834
NCT01926028
NCT01067131
NCT00614666

Software Mentioned

Epionc

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