A comprehensive phylogenetic analysis of deadenylases

Evolutionary Bioinformatics Online
Athanasia PavlopoulouSophia Kossida

Abstract

Deadenylases catalyze the shortening of the poly(A) tail at the messenger ribonucleic acid (mRNA) 3'-end in eukaryotes. Therefore, these enzymes influence mRNA decay, and constitute a major emerging group of promising anti-cancer pharmacological targets. Herein, we conducted full phylogenetic analyses of the deadenylase homologs in all available genomes in an effort to investigate evolutionary relationships between the deadenylase families and to identify invariant residues, which probably play key roles in the function of deadenylation across species. Our study includes both major Asp-Glu-Asp-Asp (DEDD) and exonuclease-endonuclease-phospatase (EEP) deadenylase superfamilies. The phylogenetic analysis has provided us with important information regarding conserved and invariant deadenylase amino acids across species. Knowledge of the phylogenetic properties and evolution of the domain of deadenylases provides the foundation for the targeted drug design in the pharmaceutical industry and modern exonuclease anti-cancer scientific research.

References

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Apr 1, 1998·Bioinformatics·D H Huson
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·L BergerH Parkes
Dec 22, 1999·Emerging Infectious Diseases·P DaszakR Speare
Feb 27, 2001·Nucleic Acids Research·Y Zuo, M P Deutscher
Dec 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·B Knudsen, M M Miyamoto
Oct 30, 2003·The Journal of Biological Chemistry·Naoyuki UchidaToshiaki Katada
Dec 9, 2003·Molecular Biology and Evolution·David Bryant, Vincent Moulton
Jun 3, 2004·Genome Research·Gavin E CrooksSteven E Brenner
Jan 25, 2007·Nature Reviews. Molecular Cell Biology·Nicole L GarneauCarol J Wilusz
Nov 24, 2007·BMC Bioinformatics·Daniel H HusonRegula Rupp
Mar 13, 2008·Nature Reviews. Molecular Cell Biology·Aaron C Goldstrohm, Marvin Wickens
Mar 28, 2008·Molecular Biology and Evolution·Si Quang Le, Olivier Gascuel
Jun 26, 2009·BMC Bioinformatics·Steve PettiferTeresa K Attwood
Nov 13, 2010·Nucleic Acids Research·Dennis A BensonEric W Sayers
Mar 31, 2011·Database : the Journal of Biological Databases and Curation·Michele Magrane, Uniprot Consortium
Oct 1, 2011·Wiley Interdisciplinary Reviews. RNA·Chyi-Ying A Chen, Ann-Bin Shyu
Nov 19, 2011·Nucleic Acids Research·Sarah HunterSiew-Yit Yong
Dec 6, 2011·Nucleic Acids Research·Scott Federhen

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Citations

Aug 16, 2016·Nucleic Acids Research·Dimitrios AnastasakisConstantinos Stathopoulos
Oct 30, 2018·Nucleic Acids Research·Tingting DengZhou Songyang

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Software Mentioned

CINEMA
CLUSTALW
PARN
WebLogo3
SplitsTree4
Gblocks
PhyML
Dendroscope
Utopia suite
BLASTp

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